Expression Level of Small Envelope Protein in Addition to Sequence Divergence inside Its Major Hydrophilic Region Contributes to More Efficient Surface Antigen Secretion by Hepatitis B Virus Subgenotype D2 than Subgenotype A2

Expression Level of Small Envelope Protein in Addition to Sequence Divergence inside Its Major Hydrophilic Region Contributes to More Efficient Surface Antigen Secretion by Hepatitis B Virus Subgenotype D2 than Subgenotype A2

Hepatitis B surface antigen (HBsAg) promotes persistent hepatitis B virus (HBV) infection. It primarily corresponds to small (S) envelope protein secreted as subviral particles. We previously found that genotype D clones expressed less S protein than genotype A clones but showed higher extracellular...

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Bibliographic Details
Main Authors: Qianru Wang, Shuwen Fu, Jing Zhang, Quan Yuan, Jisu Li, Ningshao Xia, Yu-Mei Wen, Yongxiang Wang, Shuping Tong
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
hepatitis B virus
hepatitis B surface antigen
small envelope protein
large envelope protein
genotype
mutation
Online Access:https://www.mdpi.com/1999-4915/12/9/967

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https://www.mdpi.com/1999-4915/12/9/967

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