Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides
The paper emphasizes on the synthesis of Palladium(II) iodide complexes containing based ligands. The new compounds of general formulae [Pd(L)4]I2 where L = Thiourea (Tu), Methylthiourea (Metu), Dimethylthiourea (Dmtu), Tetramethylthiourea (Tmtu), Imidazolidine-2-thione (Imt), Mercaptopyridine (Mpy)...
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2016-09-01
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doaj-4ab2ae007ea740b0a28dc048b141bcdc2021-01-02T06:41:48ZengTaylor & Francis GroupAlexandria Journal of Medicine2090-50682016-09-0152327928810.1016/j.ajme.2015.10.003Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamidesShafqat Nadeem0Muhammad Sirajuddin1Saeed Ahmad2Syed Ahmed Tirmizi3Muhammad Irshad Ali4Abdul Hameed5Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, University of Science & Technology, Bannu, PakistanDepartment of Chemistry, University of Engineering and Technology, Lahore 54890, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanDepartment of Chemistry, Quaid-i-Azam University, Islamabad 45320, PakistanMicrobiology Research Laboratory, Department of Microbiology, Quaid-i-Azam University, Islamabad 45320, PakistanThe paper emphasizes on the synthesis of Palladium(II) iodide complexes containing based ligands. The new compounds of general formulae [Pd(L)4]I2 where L = Thiourea (Tu), Methylthiourea (Metu), Dimethylthiourea (Dmtu), Tetramethylthiourea (Tmtu), Imidazolidine-2-thione (Imt), Mercaptopyridine (Mpy), Mercaptopyrimidine (Mpm), and Thionicotinamide (Tna) were prepared simply by reacting K2[PdCl4] with the corresponding thioamides in 1:2 M ratio and then with 2 equivalents Potassium iodide. The complexes were characterized by elemental analysis and spectroscopic techniques (IR, 1H and13C NMR). All the synthesized complexes were screened for antibacterial activity and some of compounds have shown good activities against both gram positive and gram negative bacteria. POM analyses reveal that the compounds are only slightly toxic and present a potential for antibacterial activity. Moreover, they have 16–23% drug score which is an important parameter for the compound possessing the drug properties.http://www.sciencedirect.com/science/article/pii/S2090506815000792Palladium complexesHeterocyclic thionesAntibacterial activityPetra/Osiris/Molinspiration analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shafqat Nadeem Muhammad Sirajuddin Saeed Ahmad Syed Ahmed Tirmizi Muhammad Irshad Ali Abdul Hameed |
spellingShingle |
Shafqat Nadeem Muhammad Sirajuddin Saeed Ahmad Syed Ahmed Tirmizi Muhammad Irshad Ali Abdul Hameed Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides Alexandria Journal of Medicine Palladium complexes Heterocyclic thiones Antibacterial activity Petra/Osiris/Molinspiration analysis |
author_facet |
Shafqat Nadeem Muhammad Sirajuddin Saeed Ahmad Syed Ahmed Tirmizi Muhammad Irshad Ali Abdul Hameed |
author_sort |
Shafqat Nadeem |
title |
Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides |
title_short |
Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides |
title_full |
Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides |
title_fullStr |
Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides |
title_full_unstemmed |
Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides |
title_sort |
synthesis, spectral characterization and in vitro antibacterial evaluation and petra/osiris/molinspiration analyses of new palladium(ii) iodide complexes with thioamides |
publisher |
Taylor & Francis Group |
series |
Alexandria Journal of Medicine |
issn |
2090-5068 |
publishDate |
2016-09-01 |
description |
The paper emphasizes on the synthesis of Palladium(II) iodide complexes containing based ligands. The new compounds of general formulae [Pd(L)4]I2 where L = Thiourea (Tu), Methylthiourea (Metu), Dimethylthiourea (Dmtu), Tetramethylthiourea (Tmtu), Imidazolidine-2-thione (Imt), Mercaptopyridine (Mpy), Mercaptopyrimidine (Mpm), and Thionicotinamide (Tna) were prepared simply by reacting K2[PdCl4] with the corresponding thioamides in 1:2 M ratio and then with 2 equivalents Potassium iodide. The complexes were characterized by elemental analysis and spectroscopic techniques (IR, 1H and13C NMR). All the synthesized complexes were screened for antibacterial activity and some of compounds have shown good activities against both gram positive and gram negative bacteria. POM analyses reveal that the compounds are only slightly toxic and present a potential for antibacterial activity. Moreover, they have 16–23% drug score which is an important parameter for the compound possessing the drug properties. |
topic |
Palladium complexes Heterocyclic thiones Antibacterial activity Petra/Osiris/Molinspiration analysis |
url |
http://www.sciencedirect.com/science/article/pii/S2090506815000792 |
work_keys_str_mv |
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