microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases
Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an...
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doaj-4ac94eec49ce4ee1819ca81adbaf884d2020-11-24T20:54:10ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2017-06-01410.3389/fmed.2017.00074269605microRNA in Cardiovascular Aging and Age-Related Cardiovascular DiseasesClaudio de Lucia0Claudio de Lucia1Klara Komici2Giulia Borghetti3Grazia Daniela Femminella4Leonardo Bencivenga5Alessandro Cannavo6Alessandro Cannavo7Graziamaria Corbi8Nicola Ferrara9Nicola Ferrara10Steven R. Houser11Walter J. Koch12Giuseppe Rengo13Giuseppe Rengo14Division of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United StatesDivision of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyCardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United StatesDivision of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyDivision of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyDivision of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United StatesDepartment of Medicine and Health Sciences, University of Molise, Campobasso, ItalyDivision of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyScientific Institute of Telese Terme, Salvatore Maugeri Foundation, IRCCS, Benevento, ItalyCardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United StatesCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United StatesDivision of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Naples, ItalyScientific Institute of Telese Terme, Salvatore Maugeri Foundation, IRCCS, Benevento, ItalyOver the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions. In this review, we will focus on the role of miRNAs in aging and age-related CVDs as heart failure, hypertension, atherosclerosis, atrial fibrillation, and diabetes mellitus. miRNAs are key regulators of complex biological mechanisms, representing an exciting potential therapeutic target in CVDs. Moreover, one major challenge in geriatric medicine is to find reliable biomarkers for diagnosis, prognosis, and prediction of the response to specific drugs. miRNAs represent a very promising tool due to their stability in the circulation and unique signature in CVDs. However, further studies are needed to investigate their translational potential in the real clinical practice.http://journal.frontiersin.org/article/10.3389/fmed.2017.00074/fullmicroRNAagingcardiovascular diseasesheart failureatherosclerosishypertension |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Claudio de Lucia Claudio de Lucia Klara Komici Giulia Borghetti Grazia Daniela Femminella Leonardo Bencivenga Alessandro Cannavo Alessandro Cannavo Graziamaria Corbi Nicola Ferrara Nicola Ferrara Steven R. Houser Walter J. Koch Giuseppe Rengo Giuseppe Rengo |
spellingShingle |
Claudio de Lucia Claudio de Lucia Klara Komici Giulia Borghetti Grazia Daniela Femminella Leonardo Bencivenga Alessandro Cannavo Alessandro Cannavo Graziamaria Corbi Nicola Ferrara Nicola Ferrara Steven R. Houser Walter J. Koch Giuseppe Rengo Giuseppe Rengo microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases Frontiers in Medicine microRNA aging cardiovascular diseases heart failure atherosclerosis hypertension |
author_facet |
Claudio de Lucia Claudio de Lucia Klara Komici Giulia Borghetti Grazia Daniela Femminella Leonardo Bencivenga Alessandro Cannavo Alessandro Cannavo Graziamaria Corbi Nicola Ferrara Nicola Ferrara Steven R. Houser Walter J. Koch Giuseppe Rengo Giuseppe Rengo |
author_sort |
Claudio de Lucia |
title |
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases |
title_short |
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases |
title_full |
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases |
title_fullStr |
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases |
title_full_unstemmed |
microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases |
title_sort |
microrna in cardiovascular aging and age-related cardiovascular diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2017-06-01 |
description |
Over the last decades, life expectancy has significantly increased although several chronic diseases persist in the population, with aging as the leading risk factor. Despite improvements in diagnosis and treatment, many elderlies suffer from cardiovascular problems that are much more frequent in an older, more fragile organism. In the long term, age-related cardiovascular diseases (CVDs) contribute to the decline of quality of life and ability to perform normal activities of daily living. microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at the posttranscriptional level in both physiological and pathological conditions. In this review, we will focus on the role of miRNAs in aging and age-related CVDs as heart failure, hypertension, atherosclerosis, atrial fibrillation, and diabetes mellitus. miRNAs are key regulators of complex biological mechanisms, representing an exciting potential therapeutic target in CVDs. Moreover, one major challenge in geriatric medicine is to find reliable biomarkers for diagnosis, prognosis, and prediction of the response to specific drugs. miRNAs represent a very promising tool due to their stability in the circulation and unique signature in CVDs. However, further studies are needed to investigate their translational potential in the real clinical practice. |
topic |
microRNA aging cardiovascular diseases heart failure atherosclerosis hypertension |
url |
http://journal.frontiersin.org/article/10.3389/fmed.2017.00074/full |
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