Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition

Osteopontin (OPN) plays an important functional role in both physiologic and pathologic states. OPN is implicated in the progression of fibrosis, cancer, and metastatic disease in several organ systems. The epithelial-mesenchymal transition (EMT), first described in embryology, is increasingly being...

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Bibliographic Details
Main Authors: Anai N. Kothari, Matthew L. Arffa, Victor Chang, Robert H. Blackwell, Wing-Kin Syn, Jiwang Zhang, Zhiyong Mi, Paul C. Kuo
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Journal of Clinical Medicine
Subjects:
osteopontin
epithelial-mesenchymal transition
cancer-associated fibroblasts
tumor microenvironment
tumor metastasis
fibrosis
Online Access:http://www.mdpi.com/2077-0383/5/4/39

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http://www.mdpi.com/2077-0383/5/4/39

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