Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

The authors present a method for the conversion of full-length tau protein into seeding-competent amyloid fibrils without heparin or other negatively charged co-factors, which could be useful for studying the effects of post-translational modifications on Tau aggregation as well as to identify poten...

Full description

Bibliographic Details
Main Authors: Pijush Chakraborty, Gwladys Rivière, Shu Liu, Alain Ibáñez de Opakua, Rıza Dervişoğlu, Alina Hebestreit, Loren B. Andreas, Ina M. Vorberg, Markus Zweckstetter
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24362-8

Internet

https://doi.org/10.1038/s41467-021-24362-8

Similar Items