Effect of Tetracycline and Vitamin E on Spatial Memory, Learning, and Depression in Wistar Rats

• Main Authors: Neda Naderi, Mehdi Mohammadzadeh, Samad Zare, Minoo Elkhanipoor
• Format: Article
• Language: fas
• Published: Qom University of Medical Sciences 2015-12-01
• Series: Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum
• Subjects: tetracycline; vitamin e; memory; learning; depression; rats
• Online Access: http://journal.muq.ac.ir/browse.php?a_code=A-10-24-27&slc_lang=en&sid=1

Background and Objectives: Tetracyclines are antibiotics that are widely used. Tetracycline, easily passes the blood-brain barrier and protects the nervous system due to its specific chemical structure. Vitamin E is one of the fat-soluble vitamins. This vitamin helps prevent the progression of Alzheimer&#039;s disease. The purpose of the present study is to investigate the effects of tetracycline and vitamin E on spatial memory, learning, and depression. &nbsp; Methods: In this experimental study, 21 male Wistar rats were randomly divided into 3 groups of 7 each. The effect of tetracycline and vitamin E on memory, learning, and depression was investigated using 8-arm radial maze and elevated plus maze. Data were analyzed by one-way ANOVA and Tukey&#039;s statistical tests. Statistical significance level was considered p<0.05. &nbsp; Results: After 21 days of treatment, it was shown that tetracycline antibiotic has a significant effect on memory. Also Vitamin E significantly reduced depression and its protective effect decreased the adverse effect of tetracycline. In the treatment group, vitamin E along with tetracycline had a significant effect on memory loss. &nbsp; Conclusion: The results of the present study indicated that use of vitamin E can reduce depression by its antioxidant and protective effects. Tetracycline also significantly increases memory. Therefore, according to the results, it is suggested that tetracycline be used along with vitamin E to reduce negative effects of the drug.