Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.
Post-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injur...
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doaj-4ae47c2905b2471699d7b3b6e8a363352020-11-25T01:32:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6547010.1371/journal.pone.0065470Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury.Arnaud MesséSophie CaplainMélanie Pélégrini-IssacSophie BlanchoRichard LévyNozar AghakhaniMichèle MontreuilHabib BenaliStéphane LehéricyPost-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injury in patients with post-concussion syndrome using resting-state functional magnetic resonance imaging data. We investigated 17 injured patients with persistent post-concussion syndrome (under the DSM-IV criteria) at 6 months post-injury compared with 38 mild traumatic brain injury patients with no post-concussion syndrome and 34 healthy controls. All patients underwent magnetic resonance imaging examinations at the subacute (1-3 weeks) and late (6 months) phases after injury. Group-wise differences in functional brain networks were analyzed using graph theory measures. Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients. Mild traumatic brain injury patients with post-concussion syndrome had greater alterations than patients without post-concussion syndrome. In patients with post-concussion syndrome, changes specifically affected temporal and thalamic regions predominantly at the subacute stage and frontal regions at the late phase. Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients.http://europepmc.org/articles/PMC3675039?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arnaud Messé Sophie Caplain Mélanie Pélégrini-Issac Sophie Blancho Richard Lévy Nozar Aghakhani Michèle Montreuil Habib Benali Stéphane Lehéricy |
spellingShingle |
Arnaud Messé Sophie Caplain Mélanie Pélégrini-Issac Sophie Blancho Richard Lévy Nozar Aghakhani Michèle Montreuil Habib Benali Stéphane Lehéricy Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. PLoS ONE |
author_facet |
Arnaud Messé Sophie Caplain Mélanie Pélégrini-Issac Sophie Blancho Richard Lévy Nozar Aghakhani Michèle Montreuil Habib Benali Stéphane Lehéricy |
author_sort |
Arnaud Messé |
title |
Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. |
title_short |
Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. |
title_full |
Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. |
title_fullStr |
Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. |
title_full_unstemmed |
Specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. |
title_sort |
specific and evolving resting-state network alterations in post-concussion syndrome following mild traumatic brain injury. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Post-concussion syndrome has been related to axonal damage in patients with mild traumatic brain injury, but little is known about the consequences of injury on brain networks. In the present study, our aim was to characterize changes in functional brain networks following mild traumatic brain injury in patients with post-concussion syndrome using resting-state functional magnetic resonance imaging data. We investigated 17 injured patients with persistent post-concussion syndrome (under the DSM-IV criteria) at 6 months post-injury compared with 38 mild traumatic brain injury patients with no post-concussion syndrome and 34 healthy controls. All patients underwent magnetic resonance imaging examinations at the subacute (1-3 weeks) and late (6 months) phases after injury. Group-wise differences in functional brain networks were analyzed using graph theory measures. Patterns of long-range functional networks alterations were found in all mild traumatic brain injury patients. Mild traumatic brain injury patients with post-concussion syndrome had greater alterations than patients without post-concussion syndrome. In patients with post-concussion syndrome, changes specifically affected temporal and thalamic regions predominantly at the subacute stage and frontal regions at the late phase. Our results suggest that the post-concussion syndrome is associated with specific abnormalities in functional brain network that may contribute to explain deficits typically observed in PCS patients. |
url |
http://europepmc.org/articles/PMC3675039?pdf=render |
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