The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study
Abstract Background Disrupted sleep is associated with a reciprocal influence on headaches and is one of the contributing factors in the process of chronicity. The goal of the present study was to investigate the influence of sleep on headaches using animal rapid eye movement (REM) sleep deprivation...
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doaj-4aecf6f7b8354edeae54eb89a2f199922020-11-25T01:11:52ZengBMCThe Journal of Headache and Pain1129-23691129-23772019-03-012011910.1186/s10194-019-0977-0The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical studySeong Hoon Kim0Ju Yeon Park1Hae Eun Shin2Si baek Lee3Dong Woo Ryu4Tae Won Kim5Jeong Wook Park6Department of Neurology, The Catholic University of Korea, College of Medicine, Uijeongbu St Mary’s HospitalDepartment of Neurology, The Catholic University of Korea, College of Medicine, Uijeongbu St Mary’s HospitalDepartment of Neurology, The Catholic University of Korea, College of Medicine, Uijeongbu St Mary’s HospitalDepartment of Neurology, The Catholic University of Korea, College of Medicine, Uijeongbu St Mary’s HospitalDepartment of Neurology, The Catholic University of Korea, College of Medicine, Uijeongbu St Mary’s HospitalDepartment of Neurology, The Catholic University of Korea, College of Medicine, Incheon St Mary’s HospitalDepartment of Neurology, The Catholic University of Korea, College of Medicine, Uijeongbu St Mary’s HospitalAbstract Background Disrupted sleep is associated with a reciprocal influence on headaches and is one of the contributing factors in the process of chronicity. The goal of the present study was to investigate the influence of sleep on headaches using animal rapid eye movement (REM) sleep deprivation and supradural capsaicin infusion models. Method Sprague-Dawley rats underwent REM sleep deprivation (REMSD) for 96 h. The sensory threshold to mechanical stimuli, assessed by the von Frey monofilament test, was measured during the REMSD period. Additionally, the Fos protein expression level was measured in the trigeminocervical complex, periaqueductal gray, and hypothalamus. Following supradural infusion of capsaicin, we evaluated the duration of facial allodynia for 28 days after REMSD. Results After REMSD, the sensory threshold to mechanical stimuli was significantly decreased (p < 0.01) and Fos-positivity in the posterior (p = 0.010) and dorsomedial hypothalamus (p = 0.024), ventrolateral periaqueductal gray (p = 0.016), and superficial layer of the trigeminocervical complex (p = 0.019) were significantly increased. The duration of facial allodynia induced by supradural capsaicin infusion was significantly longer in the REM sleep deprivation and capsaicin infusion group (Day 10 PSD vs. Day 25 PSD). Conclusion The present study demonstrates that REM sleep deprivation increased nociceptive transmission from trigeminal nerve endings. Furthermore, it suggests that sleep deprivation may contribute to the chronicity of facial allodynia.http://link.springer.com/article/10.1186/s10194-019-0977-0REM sleep deprivationHeadacheFacial allodyniaCapsaicin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Seong Hoon Kim Ju Yeon Park Hae Eun Shin Si baek Lee Dong Woo Ryu Tae Won Kim Jeong Wook Park |
spellingShingle |
Seong Hoon Kim Ju Yeon Park Hae Eun Shin Si baek Lee Dong Woo Ryu Tae Won Kim Jeong Wook Park The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study The Journal of Headache and Pain REM sleep deprivation Headache Facial allodynia Capsaicin |
author_facet |
Seong Hoon Kim Ju Yeon Park Hae Eun Shin Si baek Lee Dong Woo Ryu Tae Won Kim Jeong Wook Park |
author_sort |
Seong Hoon Kim |
title |
The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study |
title_short |
The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study |
title_full |
The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study |
title_fullStr |
The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study |
title_full_unstemmed |
The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study |
title_sort |
influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and fos immunohistochemical study |
publisher |
BMC |
series |
The Journal of Headache and Pain |
issn |
1129-2369 1129-2377 |
publishDate |
2019-03-01 |
description |
Abstract Background Disrupted sleep is associated with a reciprocal influence on headaches and is one of the contributing factors in the process of chronicity. The goal of the present study was to investigate the influence of sleep on headaches using animal rapid eye movement (REM) sleep deprivation and supradural capsaicin infusion models. Method Sprague-Dawley rats underwent REM sleep deprivation (REMSD) for 96 h. The sensory threshold to mechanical stimuli, assessed by the von Frey monofilament test, was measured during the REMSD period. Additionally, the Fos protein expression level was measured in the trigeminocervical complex, periaqueductal gray, and hypothalamus. Following supradural infusion of capsaicin, we evaluated the duration of facial allodynia for 28 days after REMSD. Results After REMSD, the sensory threshold to mechanical stimuli was significantly decreased (p < 0.01) and Fos-positivity in the posterior (p = 0.010) and dorsomedial hypothalamus (p = 0.024), ventrolateral periaqueductal gray (p = 0.016), and superficial layer of the trigeminocervical complex (p = 0.019) were significantly increased. The duration of facial allodynia induced by supradural capsaicin infusion was significantly longer in the REM sleep deprivation and capsaicin infusion group (Day 10 PSD vs. Day 25 PSD). Conclusion The present study demonstrates that REM sleep deprivation increased nociceptive transmission from trigeminal nerve endings. Furthermore, it suggests that sleep deprivation may contribute to the chronicity of facial allodynia. |
topic |
REM sleep deprivation Headache Facial allodynia Capsaicin |
url |
http://link.springer.com/article/10.1186/s10194-019-0977-0 |
work_keys_str_mv |
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