Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study
There is still limited data on the association between 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone health in healthy younger adults, particularly in Latin America. This cross-sectional analysis aimed to investigate the associations of 25(OH)D and plasma PTH concentrations with...
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doaj-4af5b7b4b603426e86382e9d7e713a562020-11-25T01:14:03ZengMDPI AGNutrients2072-66432019-06-01116126710.3390/nu11061267nu11061267Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL StudyMarcela M. Mendes0Kathryn H. Hart1Susan A. Lanham-New2Patrícia B. Botelho3Department of Nutritional Sciences, University of Surrey, Guildford GU2 7XH, UKDepartment of Nutritional Sciences, University of Surrey, Guildford GU2 7XH, UKDepartment of Nutritional Sciences, University of Surrey, Guildford GU2 7XH, UKPostgraduate program of the Faculty of Nutrition, Federal University of Goiás, Goiânia 74605-080, BrazilThere is still limited data on the association between 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone health in healthy younger adults, particularly in Latin America. This cross-sectional analysis aimed to investigate the associations of 25(OH)D and plasma PTH concentrations with bone parameters, and potential confounders, in women living in a high (England) or low (Brazil) latitude country. Bone was assessed by either peripheral quantitative computed tomography (pQCT) (England) or dual-energy x-ray absorptiometry (DXA) scan (Brazil), serum 25(OH)D concentrations by high performance liquid chromatography tandem mass spectrometry (HPLC-MS) and PTH by the chemiluminescent method. In participants living in England, total volumetric bone mineral density (vBMD) was significantly higher in women <29 years compared to ≥30 years, and total and cortical vBMD values at the 66% site were negatively correlated with weight and body mass index (BMI). In participants living in Brazil, age was positively correlated with bone mineral density (BMD) at the femur and bone mineral content (BMC), and weight, BMI, and body fat were correlated with BMD (lumbar spine and femur) and BMC. PTH concentrations were negatively correlated with 25(OH)D concentrations, and the prevalence of secondary hyperparathyroidism was 28.6% (<i>n</i> = 14) in participants with concentrations <25 nmol/L and 12.2% (<i>n</i> = 41) with concentrations between 25 and 49.9 nmol/L, compared to 6.3% (<i>n</i> = 79) in those with concentrations ≥50 nmol/L. In conclusion, weight and BMI were significantly correlated with bone parameters in both groups and age was significantly correlated with BMD at the femoral neck for women living in Brazil only. Although 25(OH)D concentrations were not correlated to bone parameters at any sites, in either country, PTH concentrations showed a significant correlation with total vBMD at the 66% site for women living in England. Secondary hyperparathyroidism was more common amongst those with deficient and insufficient vitamin D status.https://www.mdpi.com/2072-6643/11/6/126725-hydroxyvitamin Dparathyroid hormonebonevitamin DBrazilbone mineral density |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcela M. Mendes Kathryn H. Hart Susan A. Lanham-New Patrícia B. Botelho |
spellingShingle |
Marcela M. Mendes Kathryn H. Hart Susan A. Lanham-New Patrícia B. Botelho Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study Nutrients 25-hydroxyvitamin D parathyroid hormone bone vitamin D Brazil bone mineral density |
author_facet |
Marcela M. Mendes Kathryn H. Hart Susan A. Lanham-New Patrícia B. Botelho |
author_sort |
Marcela M. Mendes |
title |
Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study |
title_short |
Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study |
title_full |
Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study |
title_fullStr |
Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study |
title_full_unstemmed |
Association between 25-Hydroxyvitamin D, Parathyroid Hormone, Vitamin D and Calcium Intake, and Bone Density in Healthy Adult Women: A Cross-Sectional Analysis from the D-SOL Study |
title_sort |
association between 25-hydroxyvitamin d, parathyroid hormone, vitamin d and calcium intake, and bone density in healthy adult women: a cross-sectional analysis from the d-sol study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-06-01 |
description |
There is still limited data on the association between 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), and bone health in healthy younger adults, particularly in Latin America. This cross-sectional analysis aimed to investigate the associations of 25(OH)D and plasma PTH concentrations with bone parameters, and potential confounders, in women living in a high (England) or low (Brazil) latitude country. Bone was assessed by either peripheral quantitative computed tomography (pQCT) (England) or dual-energy x-ray absorptiometry (DXA) scan (Brazil), serum 25(OH)D concentrations by high performance liquid chromatography tandem mass spectrometry (HPLC-MS) and PTH by the chemiluminescent method. In participants living in England, total volumetric bone mineral density (vBMD) was significantly higher in women <29 years compared to ≥30 years, and total and cortical vBMD values at the 66% site were negatively correlated with weight and body mass index (BMI). In participants living in Brazil, age was positively correlated with bone mineral density (BMD) at the femur and bone mineral content (BMC), and weight, BMI, and body fat were correlated with BMD (lumbar spine and femur) and BMC. PTH concentrations were negatively correlated with 25(OH)D concentrations, and the prevalence of secondary hyperparathyroidism was 28.6% (<i>n</i> = 14) in participants with concentrations <25 nmol/L and 12.2% (<i>n</i> = 41) with concentrations between 25 and 49.9 nmol/L, compared to 6.3% (<i>n</i> = 79) in those with concentrations ≥50 nmol/L. In conclusion, weight and BMI were significantly correlated with bone parameters in both groups and age was significantly correlated with BMD at the femoral neck for women living in Brazil only. Although 25(OH)D concentrations were not correlated to bone parameters at any sites, in either country, PTH concentrations showed a significant correlation with total vBMD at the 66% site for women living in England. Secondary hyperparathyroidism was more common amongst those with deficient and insufficient vitamin D status. |
topic |
25-hydroxyvitamin D parathyroid hormone bone vitamin D Brazil bone mineral density |
url |
https://www.mdpi.com/2072-6643/11/6/1267 |
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