Novel Optineurin Frameshift Insertion in a Family With Frontotemporal Dementia and Parkinsonism Without Amyotrophic Lateral Sclerosis

Novel Optineurin Frameshift Insertion in a Family With Frontotemporal Dementia and Parkinsonism Without Amyotrophic Lateral Sclerosis

Frontotemporal Dementia (FTD) is a common cause of Young Onset Dementia and has diverse clinical manifestations involving behavior, executive function, language and motor function, including parkinsonism. Up to 50% of FTD patients report a positive family history, supporting a strong genetic basis,...

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Bibliographic Details
Main Authors: Jacqueline Dominguez, Jeryl Tan Yu, Yi Jayne Tan, Arlene Ng, Ma Fe De Guzman, Boots Natividad, Ma Luisa Daroy, Jemellee Cano, Justine Yu, Michelle M. Lian, Li Zeng, Weng Khong Lim, Jia Nee Foo, Adeline S. L. Ng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neurology
Subjects:
familial FTD
novel mutation
parkinsonism
amyotrophic lateral scelerosis
optineurin (OPTN)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.645913/full

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