Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients
Background/Aims: The immune response to influenza vaccine may be influenced by many factors, e.g. age, comorbidities or inflammation, and iron status. Methods: We studied the vaccine-induced production of hemagglutination-inhibition antibodies (HI) in 133 hemodialysis patients (HD) and 40 controls....
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2016-02-01
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doaj-4b064d2d86ba47939edf2cb31894ce3e2020-11-25T03:19:00ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432016-02-0141213914710.1159/000443416443416Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis PatientsJaromír EiseltLukáš KielbergerDaniel RajdlJaroslav RacekPetr PazdioraLada MalánováBackground/Aims: The immune response to influenza vaccine may be influenced by many factors, e.g. age, comorbidities or inflammation, and iron status. Methods: We studied the vaccine-induced production of hemagglutination-inhibition antibodies (HI) in 133 hemodialysis patients (HD) and 40 controls. To identify variables associated with the immune response, uni- and multivariate regression analyses were performed with seroconversion in HI titers as a dependent variable, with demographics, comorbidities, previous vaccination, inflammation, and iron status as independent variables. Results: Seroconversion rates were lower in HD than in controls [43% versus 73% (H1N1 strain; p Conclusion: The influenza vaccine-induced antibody production was lower in HD than in controls and was independent of inflammation and iron status in both groups. Besides dependence on dialysis, the variables associated with inferior seroconversion rates included pre-vaccination seroprotection, previous vaccination, and old age.http://www.karger.com/Article/FullText/443416Influenza vaccineImmune responseInflammationFerritinIron metabolismHemodialysisPost-vaccination seroconversion |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jaromír Eiselt Lukáš Kielberger Daniel Rajdl Jaroslav Racek Petr Pazdiora Lada Malánová |
spellingShingle |
Jaromír Eiselt Lukáš Kielberger Daniel Rajdl Jaroslav Racek Petr Pazdiora Lada Malánová Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients Kidney & Blood Pressure Research Influenza vaccine Immune response Inflammation Ferritin Iron metabolism Hemodialysis Post-vaccination seroconversion |
author_facet |
Jaromír Eiselt Lukáš Kielberger Daniel Rajdl Jaroslav Racek Petr Pazdiora Lada Malánová |
author_sort |
Jaromír Eiselt |
title |
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients |
title_short |
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients |
title_full |
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients |
title_fullStr |
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients |
title_full_unstemmed |
Previous Vaccination and Age are More Important Predictors of Immune Response to Influenza Vaccine than Inflammation and Iron Status in Dialysis Patients |
title_sort |
previous vaccination and age are more important predictors of immune response to influenza vaccine than inflammation and iron status in dialysis patients |
publisher |
Karger Publishers |
series |
Kidney & Blood Pressure Research |
issn |
1420-4096 1423-0143 |
publishDate |
2016-02-01 |
description |
Background/Aims: The immune response to influenza vaccine may be influenced by many factors, e.g. age, comorbidities or inflammation, and iron status. Methods: We studied the vaccine-induced production of hemagglutination-inhibition antibodies (HI) in 133 hemodialysis patients (HD) and 40 controls. To identify variables associated with the immune response, uni- and multivariate regression analyses were performed with seroconversion in HI titers as a dependent variable, with demographics, comorbidities, previous vaccination, inflammation, and iron status as independent variables. Results: Seroconversion rates were lower in HD than in controls [43% versus 73% (H1N1 strain; p Conclusion: The influenza vaccine-induced antibody production was lower in HD than in controls and was independent of inflammation and iron status in both groups. Besides dependence on dialysis, the variables associated with inferior seroconversion rates included pre-vaccination seroprotection, previous vaccination, and old age. |
topic |
Influenza vaccine Immune response Inflammation Ferritin Iron metabolism Hemodialysis Post-vaccination seroconversion |
url |
http://www.karger.com/Article/FullText/443416 |
work_keys_str_mv |
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