Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection
Viral infections may cause neurological disorders by directly inducing oxidative stress and interrupting immune system function, both of which contribute to neuronal death. Several reports have described the neurological manifestations in Covid-19 patients where, in severe cases of the infection, br...
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MDPI AG
2021-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/1/47 |
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doaj-4b155fdf00894121b4d43634c217e1ba2021-01-03T00:01:50ZengMDPI AGAntioxidants2076-39212021-01-0110474710.3390/antiox10010047Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 InfectionPrapimpun Wongchitrat0Mayuri Shukla1Ramaswamy Sharma2Piyarat Govitrapong3Russel J. Reiter4Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, ThailandChulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, ThailandDepartment of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USAChulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok 10210, ThailandDepartment of Cell Systems & Anatomy, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USAViral infections may cause neurological disorders by directly inducing oxidative stress and interrupting immune system function, both of which contribute to neuronal death. Several reports have described the neurological manifestations in Covid-19 patients where, in severe cases of the infection, brain inflammation and encephalitis are common. Recently, extensive research-based studies have revealed and acknowledged the clinical and preventive roles of melatonin in some viral diseases. Melatonin has been shown to have antiviral properties against several viral infections which are accompanied by neurological symptoms. The beneficial properties of melatonin relate to its properties as a potent antioxidant, anti-inflammatory, and immunoregulatory molecule and its neuroprotective effects. In this review, what is known about the therapeutic role of melatonin in virus-induced neuropathogenesis is summarized and discussed.https://www.mdpi.com/2076-3921/10/1/47melatoninCovid-19neurodegenerationviral infectionoxidative stressreactive oxygen species |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Prapimpun Wongchitrat Mayuri Shukla Ramaswamy Sharma Piyarat Govitrapong Russel J. Reiter |
| spellingShingle |
Prapimpun Wongchitrat Mayuri Shukla Ramaswamy Sharma Piyarat Govitrapong Russel J. Reiter Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection Antioxidants melatonin Covid-19 neurodegeneration viral infection oxidative stress reactive oxygen species |
| author_facet |
Prapimpun Wongchitrat Mayuri Shukla Ramaswamy Sharma Piyarat Govitrapong Russel J. Reiter |
| author_sort |
Prapimpun Wongchitrat |
| title |
Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection |
| title_short |
Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection |
| title_full |
Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection |
| title_fullStr |
Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection |
| title_full_unstemmed |
Role of Melatonin on Virus-Induced Neuropathogenesis—A Concomitant Therapeutic Strategy to Understand SARS-CoV-2 Infection |
| title_sort |
role of melatonin on virus-induced neuropathogenesis—a concomitant therapeutic strategy to understand sars-cov-2 infection |
| publisher |
MDPI AG |
| series |
Antioxidants |
| issn |
2076-3921 |
| publishDate |
2021-01-01 |
| description |
Viral infections may cause neurological disorders by directly inducing oxidative stress and interrupting immune system function, both of which contribute to neuronal death. Several reports have described the neurological manifestations in Covid-19 patients where, in severe cases of the infection, brain inflammation and encephalitis are common. Recently, extensive research-based studies have revealed and acknowledged the clinical and preventive roles of melatonin in some viral diseases. Melatonin has been shown to have antiviral properties against several viral infections which are accompanied by neurological symptoms. The beneficial properties of melatonin relate to its properties as a potent antioxidant, anti-inflammatory, and immunoregulatory molecule and its neuroprotective effects. In this review, what is known about the therapeutic role of melatonin in virus-induced neuropathogenesis is summarized and discussed. |
| topic |
melatonin Covid-19 neurodegeneration viral infection oxidative stress reactive oxygen species |
| url |
https://www.mdpi.com/2076-3921/10/1/47 |
| work_keys_str_mv |
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