Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking
<p>Abstract</p> <p>Background</p> <p>Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements of circumferentially and radially dire...
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doaj-4b1c78584d864d8483d95f9e48c796822020-11-25T02:25:38ZengBMCJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2012-06-011414310.1186/1532-429X-14-43Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature trackingMorton GeraintSchuster AndreasJogiya RoyKutty ShelbyBeerbaum PhilippNagel Eike<p>Abstract</p> <p>Background</p> <p>Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements of circumferentially and radially directed ventricular wall strain. Inter-study reproducibility is important for serial assessments however has not been defined for CMR-FT.</p> <p>Methods</p> <p>16 healthy volunteers were imaged 3 times within a single day. The first examination was performed at 0900 after fasting and was immediately followed by the second. The third, non-fasting scan, was performed at 1400.</p> <p>CMR-FT measures of segmental and global strain parameters were calculated. Left ventricular (LV) circumferential and radial strain were determined in the short axis orientation (Ecc<sub>SAX</sub> and Err<sub>SAX</sub> respectively). LV and right ventricular longitudinal strain and LV radial strain were determined from the 4-chamber orientation (Ell<sub>LV</sub>, Ell<sub>RV</sub>, and Err<sub>LAX</sub> respectively). LV volumes and function were also analysed.</p> <p>Inter-study reproducibility and study sample sizes required to demonstrate 5% changes in absolute strain were determined by comparison of the first and second exams. The third exam was used to determine whether diurnal variation affected reproducibility.</p> <p>Results</p> <p>CMR-FT strain analysis inter-study reproducibility was variable. Global strain assessment was more reproducible than segmental analysis. Overall Ecc<sub>SAX</sub> was the most reproducible measure of strain: coefficient of variation (CV) 38% and 20.3% and intraclass correlation coefficient (ICC) 0.68 (0.55-0.78) and 0.7 (0.32-0.89) for segmental and global analysis respectively. The least reproducible segmental measure was Ell<sub>RV</sub>: CV 60% and ICC 0.56 (0.41-0.69) whilst the least reproducible global measure was Err<sub>LAX</sub>: CV 33.3% and ICC 0.44 (0–0.77). Variable reproducibility was also reflected in the calculated sample sizes, which ranged from 11 (global Ecc<sub>SAX</sub>) to 156 subjects (segmental Ell<sub>RV</sub>). The reproducibility of LV volumes and function was excellent. There was no diurnal variation in global strain or LV volumetric measurements.</p> <p>Conclusions</p> <p>Inter-study reproducibility of CMR-FT varied between different parameters, as summarized above and was better for global rather than segmental analysis. It was not measurably affected by diurnal variation. CMR-FT may have potential for quantitative wall motion analysis with applications in patient management and clinical trials. However, inter-study reproducibility was relatively poor for segmental and long axis analyses of strain, which have yet to be validated, and may benefit from further development.</p> http://www.jcmr-online.com/content/14/1/43 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Morton Geraint Schuster Andreas Jogiya Roy Kutty Shelby Beerbaum Philipp Nagel Eike |
spellingShingle |
Morton Geraint Schuster Andreas Jogiya Roy Kutty Shelby Beerbaum Philipp Nagel Eike Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking Journal of Cardiovascular Magnetic Resonance |
author_facet |
Morton Geraint Schuster Andreas Jogiya Roy Kutty Shelby Beerbaum Philipp Nagel Eike |
author_sort |
Morton Geraint |
title |
Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking |
title_short |
Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking |
title_full |
Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking |
title_fullStr |
Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking |
title_full_unstemmed |
Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking |
title_sort |
inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking |
publisher |
BMC |
series |
Journal of Cardiovascular Magnetic Resonance |
issn |
1097-6647 1532-429X |
publishDate |
2012-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Cardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements of circumferentially and radially directed ventricular wall strain. Inter-study reproducibility is important for serial assessments however has not been defined for CMR-FT.</p> <p>Methods</p> <p>16 healthy volunteers were imaged 3 times within a single day. The first examination was performed at 0900 after fasting and was immediately followed by the second. The third, non-fasting scan, was performed at 1400.</p> <p>CMR-FT measures of segmental and global strain parameters were calculated. Left ventricular (LV) circumferential and radial strain were determined in the short axis orientation (Ecc<sub>SAX</sub> and Err<sub>SAX</sub> respectively). LV and right ventricular longitudinal strain and LV radial strain were determined from the 4-chamber orientation (Ell<sub>LV</sub>, Ell<sub>RV</sub>, and Err<sub>LAX</sub> respectively). LV volumes and function were also analysed.</p> <p>Inter-study reproducibility and study sample sizes required to demonstrate 5% changes in absolute strain were determined by comparison of the first and second exams. The third exam was used to determine whether diurnal variation affected reproducibility.</p> <p>Results</p> <p>CMR-FT strain analysis inter-study reproducibility was variable. Global strain assessment was more reproducible than segmental analysis. Overall Ecc<sub>SAX</sub> was the most reproducible measure of strain: coefficient of variation (CV) 38% and 20.3% and intraclass correlation coefficient (ICC) 0.68 (0.55-0.78) and 0.7 (0.32-0.89) for segmental and global analysis respectively. The least reproducible segmental measure was Ell<sub>RV</sub>: CV 60% and ICC 0.56 (0.41-0.69) whilst the least reproducible global measure was Err<sub>LAX</sub>: CV 33.3% and ICC 0.44 (0–0.77). Variable reproducibility was also reflected in the calculated sample sizes, which ranged from 11 (global Ecc<sub>SAX</sub>) to 156 subjects (segmental Ell<sub>RV</sub>). The reproducibility of LV volumes and function was excellent. There was no diurnal variation in global strain or LV volumetric measurements.</p> <p>Conclusions</p> <p>Inter-study reproducibility of CMR-FT varied between different parameters, as summarized above and was better for global rather than segmental analysis. It was not measurably affected by diurnal variation. CMR-FT may have potential for quantitative wall motion analysis with applications in patient management and clinical trials. However, inter-study reproducibility was relatively poor for segmental and long axis analyses of strain, which have yet to be validated, and may benefit from further development.</p> |
url |
http://www.jcmr-online.com/content/14/1/43 |
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