Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter h...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07295-7 |
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doaj-4b205c6e06da4bc4a5c5e12d398631402021-05-11T09:50:34ZengNature Publishing GroupNature Communications2041-17232018-11-019111310.1038/s41467-018-07295-7Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cellsHarald Lund0Melanie Pieber1Roham Parsa2Jinming Han3David Grommisch4Ewoud Ewing5Lara Kular6Maria Needhamsen7Alexander Espinosa8Emma Nilsson9Anna K. Överby10Oleg Butovsky11Maja Jagodic12Xing-Mei Zhang13Robert A. Harris14Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaUnit of Rheumatology, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaDepartment of Clinical Microbiology, Virology, Umeå UniversityDepartment of Clinical Microbiology, Virology, Umeå UniversityAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital SolnaBrain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter having overlapping but distinct characteristics.https://doi.org/10.1038/s41467-018-07295-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Harald Lund Melanie Pieber Roham Parsa Jinming Han David Grommisch Ewoud Ewing Lara Kular Maria Needhamsen Alexander Espinosa Emma Nilsson Anna K. Överby Oleg Butovsky Maja Jagodic Xing-Mei Zhang Robert A. Harris |
| spellingShingle |
Harald Lund Melanie Pieber Roham Parsa Jinming Han David Grommisch Ewoud Ewing Lara Kular Maria Needhamsen Alexander Espinosa Emma Nilsson Anna K. Överby Oleg Butovsky Maja Jagodic Xing-Mei Zhang Robert A. Harris Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells Nature Communications |
| author_facet |
Harald Lund Melanie Pieber Roham Parsa Jinming Han David Grommisch Ewoud Ewing Lara Kular Maria Needhamsen Alexander Espinosa Emma Nilsson Anna K. Överby Oleg Butovsky Maja Jagodic Xing-Mei Zhang Robert A. Harris |
| author_sort |
Harald Lund |
| title |
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells |
| title_short |
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells |
| title_full |
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells |
| title_fullStr |
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells |
| title_full_unstemmed |
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells |
| title_sort |
competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-11-01 |
| description |
Brain microglial cells can be replenished by blood-derived monocytes, but many aspects of this repopulation remain unclear. Here the authors show that the brain microglial niche can be replaced both by proliferating, residential microglia as well as differentiated Ly6Chi monocytes, with the latter having overlapping but distinct characteristics. |
| url |
https://doi.org/10.1038/s41467-018-07295-7 |
| work_keys_str_mv |
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