Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties

Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties

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A series of novel N-((2,5-diaryl-3-trifluoroacetyl)-1H-indol-7-yl)acetamides has been prepared via a successive and one-pot reaction sequence involving initial trifluoroacetic acid-mediated Beckmann rearrangement of the oximes derived from the 1-(2,5-diaryl-1H-indol-7-yl)ethanones, followed by trifl...

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Bibliographic Details
Main Authors: Malose J. Mphahlele, Mmakwena M. Mmonwa, Yee Siew Choong
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
N-(2,5-diaryl-1H-indol-7-yl)acetamides
N-(3-trifluoroacetylindol-7-yl)acetamides
antiplasmodial activity
cytotoxicity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/22/7/1099
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