Genome-wide expression patterns in physiological cardiac hypertrophy

• Main Authors: Ouzounis Christos A, Tsoka Sophia, Drozdov Ignat, Shah Ajay M
• Format: Article
• Language: English
• Published: BMC 2010-10-01
• Series: BMC Genomics
• Online Access: http://www.biomedcentral.com/1471-2164/11/557

<p>Abstract</p> <p>Background</p> <p>Genome-wide expression patterns in physiological cardiac hypertrophy. Co-expression patterns in physiological cardiac hypertrophy</p> <p>Results</p> <p>In this study, the first large-scale analysis of publicly available genome-wide expression data of several <it>in vivo </it>murine models of physiological LVH was carried out using network analysis. On evaluating 3 million gene co-expression patterns across 141 relevant microarray experiments, it was found that physiological adaptation is an evolutionarily conserved processes involving preservation of the function of cytochrome c oxidase, induction of autophagy compatible with cell survival, and coordinated regulation of angiogenesis.</p> <p>Conclusion</p> <p>This analysis not only identifies known biological pathways involved in physiological LVH, but also offers novel insights into the molecular basis of this phenotype by identifying key networks of co-expressed genes, as well as their topological and functional properties, using relevant high-quality microarray experiments and network inference.</p>