Downregulation and/or Release of NKG2D Ligands as Immune Evasion Strategy of Human Neuroblastoma

Downregulation and/or Release of NKG2D Ligands as Immune Evasion Strategy of Human Neuroblastoma

Neuroblastoma (NB) is a pediatric extracranial tumor characterized by downregulation of human leukocyte antigen class I and defects of the antigen processing machinery, two features that make it an appropriate target for natural killer (NK)-mediated lysis. NKG2D is an activating immunoreceptor expr...

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Bibliographic Details
Main Authors: Lizzia Raffaghello, Ignazia Prigione, Irma Airoldi, Marta Camoriano, Isabella Levreri, Claudio Gambini, Daniela Pende, Alexander Steinle, Soldano Ferrone, Vito Pistoia
Format: Article
Language:English
Published: Elsevier 2004-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Neuroblastoma
NK ligands
tumor immune evasion
NK cell
tumor immunogenicity
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800344

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