Alphavirus-based hepatitis C virus therapeutic vaccines: can universal helper epitopes enhance HCV-specific cytotoxic T lymphocyte responses?

Background: Antigen-specific T cell immune responses play a pivotal role in resolving acute and chronic hepatitis C virus (HCV) infections. Currently, no prophylactic or therapeutic vaccines against HCV are available. We previously demonstrated the preclinical potency of therapeutic HCV vaccines bas...

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Bibliographic Details
Main Authors: Georgia Koutsoumpli, Peng Peng Ip, Ilona Schepel, Baukje Nynke Hoogeboom, Annemarie Boerma, Toos Daemen
Format: Article
Language:English
Published: SAGE Publishing 2019-10-01
Series:Therapeutic Advances in Vaccines and Immunotherapy
Online Access:https://doi.org/10.1177/2515135519874677