Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia
Interhemispheric connectivity of the two cerebral hemispheres is crucial for a broad repertoire of cognitive functions including music and language. Congenital amusia has been reported as a neurodevelopment disorder characterized by impaired music perception and production. However, little is known...
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doaj-4b599e4e82334a62bc64cce959fd63672021-04-30T07:31:34ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-04-011510.3389/fnins.2021.653325653325Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital AmusiaZhishuai Jin0Sizhu Huyang1Lichen Jiang2Yajun Yan3Ming Xu4Jinyu Wang5Qixiong Li6Daxing Wu7Daxing Wu8Daxing Wu9Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, ChinaMedical Psychological Institute, Central South University, Changsha, ChinaNational Clinical Research Center for Mental Disorders, Changsha, ChinaInterhemispheric connectivity of the two cerebral hemispheres is crucial for a broad repertoire of cognitive functions including music and language. Congenital amusia has been reported as a neurodevelopment disorder characterized by impaired music perception and production. However, little is known about the characteristics of the interhemispheric functional connectivity (FC) in amusia. In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to investigate the interhemispheric FC of the whole brain in amusia at resting-state. Thirty amusics and 29 matched participants underwent a resting-state functional magnetic resonance imaging (fMRI) scanning. An automated VMHC approach was used to analyze the fMRI data. Compared to the control group, amusics showed increased VMHC within the posterior part of the default mode network (DMN) mainly in the posterior superior temporal gyrus (pSTG) and posterior cingulate cortex (PCC). Correlation analyses revealed negative correlations between the VMHC value in pSTG/PCC and the music perception ability among amusics. Further ROC analyses showed that the VMHC value of pSTG/PCC showed a good sensibility/specificity to differentiate the amusics from the controls. These findings provide a new perspective for understanding the neural basis of congenital amusia and imply the immature state of DMN may be a credible neural marker of amusia.https://www.frontiersin.org/articles/10.3389/fnins.2021.653325/fullcongenital amusiafunctional connectivityvoxel-mirrored homotopic connectivityposterior superior temporal gyrusposterior cingulate cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhishuai Jin Sizhu Huyang Lichen Jiang Yajun Yan Ming Xu Jinyu Wang Qixiong Li Daxing Wu Daxing Wu Daxing Wu |
spellingShingle |
Zhishuai Jin Sizhu Huyang Lichen Jiang Yajun Yan Ming Xu Jinyu Wang Qixiong Li Daxing Wu Daxing Wu Daxing Wu Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia Frontiers in Neuroscience congenital amusia functional connectivity voxel-mirrored homotopic connectivity posterior superior temporal gyrus posterior cingulate cortex |
author_facet |
Zhishuai Jin Sizhu Huyang Lichen Jiang Yajun Yan Ming Xu Jinyu Wang Qixiong Li Daxing Wu Daxing Wu Daxing Wu |
author_sort |
Zhishuai Jin |
title |
Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia |
title_short |
Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia |
title_full |
Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia |
title_fullStr |
Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia |
title_full_unstemmed |
Increased Resting-State Interhemispheric Functional Connectivity of Posterior Superior Temporal Gyrus and Posterior Cingulate Cortex in Congenital Amusia |
title_sort |
increased resting-state interhemispheric functional connectivity of posterior superior temporal gyrus and posterior cingulate cortex in congenital amusia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2021-04-01 |
description |
Interhemispheric connectivity of the two cerebral hemispheres is crucial for a broad repertoire of cognitive functions including music and language. Congenital amusia has been reported as a neurodevelopment disorder characterized by impaired music perception and production. However, little is known about the characteristics of the interhemispheric functional connectivity (FC) in amusia. In the present study, we used a newly developed voxel-mirrored homotopic connectivity (VMHC) method to investigate the interhemispheric FC of the whole brain in amusia at resting-state. Thirty amusics and 29 matched participants underwent a resting-state functional magnetic resonance imaging (fMRI) scanning. An automated VMHC approach was used to analyze the fMRI data. Compared to the control group, amusics showed increased VMHC within the posterior part of the default mode network (DMN) mainly in the posterior superior temporal gyrus (pSTG) and posterior cingulate cortex (PCC). Correlation analyses revealed negative correlations between the VMHC value in pSTG/PCC and the music perception ability among amusics. Further ROC analyses showed that the VMHC value of pSTG/PCC showed a good sensibility/specificity to differentiate the amusics from the controls. These findings provide a new perspective for understanding the neural basis of congenital amusia and imply the immature state of DMN may be a credible neural marker of amusia. |
topic |
congenital amusia functional connectivity voxel-mirrored homotopic connectivity posterior superior temporal gyrus posterior cingulate cortex |
url |
https://www.frontiersin.org/articles/10.3389/fnins.2021.653325/full |
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