Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance
Abstract T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, le...
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doaj-4b5a825347db4811b2bd0474faeac5142020-12-08T00:15:17ZengNature Publishing GroupScientific Reports2045-23222017-05-017111210.1038/s41598-017-02544-zQuantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonanceRachel K. Dongworth0Adrienne E. Campbell-Washburn1Hector A. Cabrera-Fuentes2Heerajnarain Bulluck3Thomas Roberts4Anthony N. Price5Sauri Hernández-Reséndiz6Roger J. Ordidge7David L. Thomas8Derek M. Yellon9Mark F. Lythgoe10Derek J. Hausenloy11The Hatter Cardiovascular Institute, University College LondonCentre for Advanced Biomedical Imaging, University College LondonCardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical SchoolThe Hatter Cardiovascular Institute, University College LondonCentre for Advanced Biomedical Imaging, University College LondonDivision of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ HospitalCardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical SchoolCentre for Neuroscience, University of MelbourneDepartment of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College LondonThe Hatter Cardiovascular Institute, University College LondonCentre for Advanced Biomedical Imaging, University College LondonThe Hatter Cardiovascular Institute, University College LondonAbstract T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion. T2-mapping was used to quantify the edema-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment. In control animals, the AAR by T2-mapping corresponded to that delineated by histology. As expected, both IPC and CsA reduced MI size. However, IPC, but not CsA, also reduced myocardial edema leading to an underestimation of the AAR by T2-mapping. In contrast, regions of reduced myocardial perfusion delineated by cardiac ASL were able to delineate the AAR when compared to both T2-mapping and histology in control animals, and were not affected by either IPC or CsA. Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI, which unlike T2-mapping, is not affected by IPC.https://doi.org/10.1038/s41598-017-02544-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rachel K. Dongworth Adrienne E. Campbell-Washburn Hector A. Cabrera-Fuentes Heerajnarain Bulluck Thomas Roberts Anthony N. Price Sauri Hernández-Reséndiz Roger J. Ordidge David L. Thomas Derek M. Yellon Mark F. Lythgoe Derek J. Hausenloy |
spellingShingle |
Rachel K. Dongworth Adrienne E. Campbell-Washburn Hector A. Cabrera-Fuentes Heerajnarain Bulluck Thomas Roberts Anthony N. Price Sauri Hernández-Reséndiz Roger J. Ordidge David L. Thomas Derek M. Yellon Mark F. Lythgoe Derek J. Hausenloy Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance Scientific Reports |
author_facet |
Rachel K. Dongworth Adrienne E. Campbell-Washburn Hector A. Cabrera-Fuentes Heerajnarain Bulluck Thomas Roberts Anthony N. Price Sauri Hernández-Reséndiz Roger J. Ordidge David L. Thomas Derek M. Yellon Mark F. Lythgoe Derek J. Hausenloy |
author_sort |
Rachel K. Dongworth |
title |
Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance |
title_short |
Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance |
title_full |
Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance |
title_fullStr |
Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance |
title_full_unstemmed |
Quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance |
title_sort |
quantifying the area-at-risk of myocardial infarction in-vivo using arterial spin labeling cardiac magnetic resonance |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-05-01 |
description |
Abstract T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion. T2-mapping was used to quantify the edema-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment. In control animals, the AAR by T2-mapping corresponded to that delineated by histology. As expected, both IPC and CsA reduced MI size. However, IPC, but not CsA, also reduced myocardial edema leading to an underestimation of the AAR by T2-mapping. In contrast, regions of reduced myocardial perfusion delineated by cardiac ASL were able to delineate the AAR when compared to both T2-mapping and histology in control animals, and were not affected by either IPC or CsA. Therefore, ASL perfusion CMR may be an alternative method for quantifying the AAR following AMI, which unlike T2-mapping, is not affected by IPC. |
url |
https://doi.org/10.1038/s41598-017-02544-z |
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