Bimodal antagonism of PKA signalling by ARHGAP36

Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.

Bibliographic Details
Main Authors:	Rebecca L. Eccles, Maciej T. Czajkowski, Carolin Barth, Paul Markus Müller, Erik McShane, Stephan Grunwald, Patrick Beaudette, Nora Mecklenburg, Rudolf Volkmer, Kerstin Zühlke, Gunnar Dittmar, Matthias Selbach, Annette Hammes, Oliver Daumke, Enno Klussmann, Sylvie Urbé, Oliver Rocks
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12963

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spelling	doaj-4b603724ee39452aa970f9812ba070502021-05-11T11:00:47ZengNature Publishing GroupNature Communications2041-17232016-10-017111610.1038/ncomms12963Bimodal antagonism of PKA signalling by ARHGAP36Rebecca L. Eccles0Maciej T. Czajkowski1Carolin Barth2Paul Markus Müller3Erik McShane4Stephan Grunwald5Patrick Beaudette6Nora Mecklenburg7Rudolf Volkmer8Kerstin Zühlke9Gunnar Dittmar10Matthias Selbach11Annette Hammes12Oliver Daumke13Enno Klussmann14Sylvie Urbé15Oliver Rocks16Max-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineLeibniz-Institut für Molekulare PharmakologieMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineMax-Delbrück-Center for Molecular MedicineCellular and Molecular Physiology, Institute of Translational Medicine, University of LiverpoolMax-Delbrück-Center for Molecular MedicineProtein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.https://doi.org/10.1038/ncomms12963
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Rebecca L. Eccles Maciej T. Czajkowski Carolin Barth Paul Markus Müller Erik McShane Stephan Grunwald Patrick Beaudette Nora Mecklenburg Rudolf Volkmer Kerstin Zühlke Gunnar Dittmar Matthias Selbach Annette Hammes Oliver Daumke Enno Klussmann Sylvie Urbé Oliver Rocks
spellingShingle	Rebecca L. Eccles Maciej T. Czajkowski Carolin Barth Paul Markus Müller Erik McShane Stephan Grunwald Patrick Beaudette Nora Mecklenburg Rudolf Volkmer Kerstin Zühlke Gunnar Dittmar Matthias Selbach Annette Hammes Oliver Daumke Enno Klussmann Sylvie Urbé Oliver Rocks Bimodal antagonism of PKA signalling by ARHGAP36 Nature Communications
author_facet	Rebecca L. Eccles Maciej T. Czajkowski Carolin Barth Paul Markus Müller Erik McShane Stephan Grunwald Patrick Beaudette Nora Mecklenburg Rudolf Volkmer Kerstin Zühlke Gunnar Dittmar Matthias Selbach Annette Hammes Oliver Daumke Enno Klussmann Sylvie Urbé Oliver Rocks
author_sort	Rebecca L. Eccles
title	Bimodal antagonism of PKA signalling by ARHGAP36
title_short	Bimodal antagonism of PKA signalling by ARHGAP36
title_full	Bimodal antagonism of PKA signalling by ARHGAP36
title_fullStr	Bimodal antagonism of PKA signalling by ARHGAP36
title_full_unstemmed	Bimodal antagonism of PKA signalling by ARHGAP36
title_sort	bimodal antagonism of pka signalling by arhgap36
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-10-01
description	Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.
url	https://doi.org/10.1038/ncomms12963
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Bimodal antagonism of PKA signalling by ARHGAP36

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