7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice
Atopic dermatitis is an inflammatory and chronically relapsing skin disorder that commonly occurs in children; the number of atopic dermatitis patients is increasing. The cause and mechanism of atopic dermatitis have not been defined clearly, although many studies are ongoing. Epidemiological studie...
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doaj-4b6298a73fa2490eb9f13302033ea1302020-11-24T22:43:11ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/6365976365977,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga MiceBo-Bae Kim0Jong Rhan Kim1Ji Hye Kim2Young Ah Kim3Jun Seong Park4Myeong-Hun Yeom5Hyong Joo Lee6Ki Won Lee7Nam Joo Kang8School of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of KoreaWCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of KoreaSkin Research Institute, Amorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do 341-1, Republic of KoreaSkin Research Institute, Amorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do 341-1, Republic of KoreaWCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of KoreaWCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of KoreaSchool of Food Science and Biotechnology, Kyungpook National University, Daegu 702-701, Republic of KoreaAtopic dermatitis is an inflammatory and chronically relapsing skin disorder that commonly occurs in children; the number of atopic dermatitis patients is increasing. The cause and mechanism of atopic dermatitis have not been defined clearly, although many studies are ongoing. Epidemiological studies suggest that soybean and its isoflavones have immunoregulatory activities. Here, we report that 7,3′,4′-trihydroxyisoflavone (7,3′,4′-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced β-hexosaminidase secretion in RBL-2H3 cells. Moreover, 7,3′,4′-THIF significantly reduced scratching time, transepidermal water loss, and mast cell infiltration. It also decreased protease-activated receptor (PAR)-2 and IL-4 expression and increased filaggrin expression in skin lesions of NC/Nga mice. These results suggest that 7,3′,4′-THIF improves Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice.http://dx.doi.org/10.1155/2013/636597 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bo-Bae Kim Jong Rhan Kim Ji Hye Kim Young Ah Kim Jun Seong Park Myeong-Hun Yeom Hyong Joo Lee Ki Won Lee Nam Joo Kang |
spellingShingle |
Bo-Bae Kim Jong Rhan Kim Ji Hye Kim Young Ah Kim Jun Seong Park Myeong-Hun Yeom Hyong Joo Lee Ki Won Lee Nam Joo Kang 7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice Evidence-Based Complementary and Alternative Medicine |
author_facet |
Bo-Bae Kim Jong Rhan Kim Ji Hye Kim Young Ah Kim Jun Seong Park Myeong-Hun Yeom Hyong Joo Lee Ki Won Lee Nam Joo Kang |
author_sort |
Bo-Bae Kim |
title |
7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice |
title_short |
7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice |
title_full |
7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice |
title_fullStr |
7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice |
title_full_unstemmed |
7,3′,4′-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice |
title_sort |
7,3′,4′-trihydroxyisoflavone ameliorates the development of dermatophagoides farinae-induced atopic dermatitis in nc/nga mice |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
Atopic dermatitis is an inflammatory and chronically relapsing skin disorder that commonly occurs in children; the number of atopic dermatitis patients is increasing. The cause and mechanism of atopic dermatitis have not been defined clearly, although many studies are ongoing. Epidemiological studies suggest that soybean and its isoflavones have immunoregulatory activities. Here, we report that 7,3′,4′-trihydroxyisoflavone (7,3′,4′-THIF), a major metabolite of daidzin, effectively inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 production in RAW 264.7 cells, and also reduced β-hexosaminidase secretion in RBL-2H3 cells. Moreover, 7,3′,4′-THIF significantly reduced scratching time, transepidermal water loss, and mast cell infiltration. It also decreased protease-activated receptor (PAR)-2 and IL-4 expression and increased filaggrin expression in skin lesions of NC/Nga mice. These results suggest that 7,3′,4′-THIF improves Dermatophagoides farina body extract-induced atopic dermatitis in NC/Nga mice. |
url |
http://dx.doi.org/10.1155/2013/636597 |
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