Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention
Jun-jie Zhang,1,2,* Xiao-fei Gao,1,* Zhen Ge,1,2 Xiao-Min Jiang,1 Ping-xi Xiao,1,2 Nai-liang Tian,1,2 Jing Kan,2 Chi-Hang Lee,3 Shao-Liang Chen1,2 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 2Department of Cardiology, Nanjing Heart Center, Nanjing, People...
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doaj-4b65061457dc4eaaa9db36d30c2f68232020-11-24T22:33:39ZengDove Medical PressPatient Preference and Adherence1177-889X2016-05-012016Issue 187187827047Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary interventionZhang JJGao XFGe ZJiang XMXiao PXTian NLKan JLee CHChen SLJun-jie Zhang,1,2,* Xiao-fei Gao,1,* Zhen Ge,1,2 Xiao-Min Jiang,1 Ping-xi Xiao,1,2 Nai-liang Tian,1,2 Jing Kan,2 Chi-Hang Lee,3 Shao-Liang Chen1,2 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 2Department of Cardiology, Nanjing Heart Center, Nanjing, People’s Republic of China; 3Department of Cardiology, National University Heart Center, Singapore *These authors contributed equally to this work Background: There is a paucity of evidence regarding the association between obstructive sleep apnea (OSA) and patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease. We sought to investigate whether OSA affects the clinical outcomes of patients undergoing PCI.Patients and methods: All enrolled individuals treated with PCI were evaluated for OSA by polysomnography. The primary end point was defined as major adverse cardiac events (MACEs) at 2 years, including cardiac death, myocardial infarction (MI), and/or target vessel revascularization.Results: A total of 340 consecutive patients undergoing PCI were assigned to the OSA (n=152, apnea–hypopnea index ≥15) and non-OSA (n=188, apnea–hypopnea index <15) groups. The incidence of OSA in patients with coronary artery disease undergoing PCI was 44.7%. Patients in the OSA group had more three-vessel disease (34.9%), increased number of total implanted stents (3.3±2.0), and longer total stent length (83.8±53.1 mm) when compared to the non-OSA group (23.4%, P=0.020; 2.8±1.9, P=0.007; 68.7±48.4, P=0.010). After a median follow-up of 2 years, the incidence of MACEs was significantly higher in patients with OSA (25.0% vs 16.0%, P=0.038), mainly driven by the increased periprocedural MI (19.2% vs 11.2%, P=0.038) in the OSA group. By Cox regression multivariable analysis, the independent predictor of MACEs was OSA (hazard ratio: 1.962, 95% confidence interval: 1.036–3.717, P=0.039).Conclusion: There was a high prevalence of moderate-to-severe OSA in patients undergoing PCI, and OSA was associated with significantly increased MACE rate, mainly due to the increase in periprocedural MI rate. Keywords: coronary artery disease, percutaneous coronary intervention, myocardial infarction, obstructive sleep apneahttps://www.dovepress.com/obstructive-sleep-apnea-affects-the-clinical-outcomes-of-patients-unde-peer-reviewed-article-PPACoronary artery diseasepercutaneous coronary interventionmyocardial infarctionobstructive sleep apnea |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhang JJ Gao XF Ge Z Jiang XM Xiao PX Tian NL Kan J Lee CH Chen SL |
spellingShingle |
Zhang JJ Gao XF Ge Z Jiang XM Xiao PX Tian NL Kan J Lee CH Chen SL Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention Patient Preference and Adherence Coronary artery disease percutaneous coronary intervention myocardial infarction obstructive sleep apnea |
author_facet |
Zhang JJ Gao XF Ge Z Jiang XM Xiao PX Tian NL Kan J Lee CH Chen SL |
author_sort |
Zhang JJ |
title |
Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention |
title_short |
Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention |
title_full |
Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention |
title_fullStr |
Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention |
title_full_unstemmed |
Obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention |
title_sort |
obstructive sleep apnea affects the clinical outcomes of patients undergoing percutaneous coronary intervention |
publisher |
Dove Medical Press |
series |
Patient Preference and Adherence |
issn |
1177-889X |
publishDate |
2016-05-01 |
description |
Jun-jie Zhang,1,2,* Xiao-fei Gao,1,* Zhen Ge,1,2 Xiao-Min Jiang,1 Ping-xi Xiao,1,2 Nai-liang Tian,1,2 Jing Kan,2 Chi-Hang Lee,3 Shao-Liang Chen1,2 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 2Department of Cardiology, Nanjing Heart Center, Nanjing, People’s Republic of China; 3Department of Cardiology, National University Heart Center, Singapore *These authors contributed equally to this work Background: There is a paucity of evidence regarding the association between obstructive sleep apnea (OSA) and patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease. We sought to investigate whether OSA affects the clinical outcomes of patients undergoing PCI.Patients and methods: All enrolled individuals treated with PCI were evaluated for OSA by polysomnography. The primary end point was defined as major adverse cardiac events (MACEs) at 2 years, including cardiac death, myocardial infarction (MI), and/or target vessel revascularization.Results: A total of 340 consecutive patients undergoing PCI were assigned to the OSA (n=152, apnea–hypopnea index ≥15) and non-OSA (n=188, apnea–hypopnea index <15) groups. The incidence of OSA in patients with coronary artery disease undergoing PCI was 44.7%. Patients in the OSA group had more three-vessel disease (34.9%), increased number of total implanted stents (3.3±2.0), and longer total stent length (83.8±53.1 mm) when compared to the non-OSA group (23.4%, P=0.020; 2.8±1.9, P=0.007; 68.7±48.4, P=0.010). After a median follow-up of 2 years, the incidence of MACEs was significantly higher in patients with OSA (25.0% vs 16.0%, P=0.038), mainly driven by the increased periprocedural MI (19.2% vs 11.2%, P=0.038) in the OSA group. By Cox regression multivariable analysis, the independent predictor of MACEs was OSA (hazard ratio: 1.962, 95% confidence interval: 1.036–3.717, P=0.039).Conclusion: There was a high prevalence of moderate-to-severe OSA in patients undergoing PCI, and OSA was associated with significantly increased MACE rate, mainly due to the increase in periprocedural MI rate. Keywords: coronary artery disease, percutaneous coronary intervention, myocardial infarction, obstructive sleep apnea |
topic |
Coronary artery disease percutaneous coronary intervention myocardial infarction obstructive sleep apnea |
url |
https://www.dovepress.com/obstructive-sleep-apnea-affects-the-clinical-outcomes-of-patients-unde-peer-reviewed-article-PPA |
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