A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome
Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation...
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doaj-4b6c98e1b28f4e2a8ebcc7384da8503e2021-10-09T04:37:44ZengElsevierRespiratory Medicine Case Reports2213-00712021-01-0134101525A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndromeKoki Nakashima0Yuya Fujii1Masayuki Sato2Kazunari Igarashi3Motohiro Kobayashi4Tamotsu Ishizuka5Department of Respiratory Medicine, Municipal Tsuruga Hospital, 1-6-60 Mishima-cho, Tsuruga, Fukui, 914-8502, Japan; Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan; Corresponding author. 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-119, Japan.Department of Respiratory Medicine, Municipal Tsuruga Hospital, 1-6-60 Mishima-cho, Tsuruga, Fukui, 914-8502, JapanDepartment of Respiratory Medicine, Municipal Tsuruga Hospital, 1-6-60 Mishima-cho, Tsuruga, Fukui, 914-8502, Japan; Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, JapanDepartment of Respiratory Medicine, Municipal Tsuruga Hospital, 1-6-60 Mishima-cho, Tsuruga, Fukui, 914-8502, JapanDepartment of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, JapanThird Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, JapanParaneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor. Blood test results revealed anti-amphiphysin (AMPH) antibody positively, leading to the diagnosis of PNS. The disturbance of consciousness was improved with intravenous administration of steroid and immunoglobulin. To our knowledge, this is the first report of anti-AMPH antibody-positive PNS in a patient with NSCLC.http://www.sciencedirect.com/science/article/pii/S2213007121001878Paraneoplastic neurological syndrome (PNS)Amphiphysin (AMPH)Non-small cell lung cancer (NSCLC)Immune checkpoint inhibitor (ICI)Atezolizumab |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Koki Nakashima Yuya Fujii Masayuki Sato Kazunari Igarashi Motohiro Kobayashi Tamotsu Ishizuka |
spellingShingle |
Koki Nakashima Yuya Fujii Masayuki Sato Kazunari Igarashi Motohiro Kobayashi Tamotsu Ishizuka A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome Respiratory Medicine Case Reports Paraneoplastic neurological syndrome (PNS) Amphiphysin (AMPH) Non-small cell lung cancer (NSCLC) Immune checkpoint inhibitor (ICI) Atezolizumab |
author_facet |
Koki Nakashima Yuya Fujii Masayuki Sato Kazunari Igarashi Motohiro Kobayashi Tamotsu Ishizuka |
author_sort |
Koki Nakashima |
title |
A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome |
title_short |
A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome |
title_full |
A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome |
title_fullStr |
A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome |
title_full_unstemmed |
A case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome |
title_sort |
case of non-small cell lung cancer presenting anti-amphiphysin antibody-positive paraneoplastic neurological syndrome |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2021-01-01 |
description |
Paraneoplastic neurological syndrome (PNS) is associated with malignancies, such as small-cell lung cancer. However, patients with non-small cell lung cancer (NSCLC) rarely develop PNS. We herein report a 72-year-old man with NSCLC who developed disturbance of consciousness on the day of initiation of treatment with an immune checkpoint inhibitor. Blood test results revealed anti-amphiphysin (AMPH) antibody positively, leading to the diagnosis of PNS. The disturbance of consciousness was improved with intravenous administration of steroid and immunoglobulin. To our knowledge, this is the first report of anti-AMPH antibody-positive PNS in a patient with NSCLC. |
topic |
Paraneoplastic neurological syndrome (PNS) Amphiphysin (AMPH) Non-small cell lung cancer (NSCLC) Immune checkpoint inhibitor (ICI) Atezolizumab |
url |
http://www.sciencedirect.com/science/article/pii/S2213007121001878 |
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