Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria.

Negative Epistasis between Sickle and Foetal Haemoglobin Suggests a Reduction in Protection against Malaria.

Haemoglobin variants, Sickle (HbS) and foetal (HbF) have been associated with malaria protection. This study explores epistatic interactions between HbS and HbF on malaria infection.The study was conducted between March 2004 and December 2013 within the sickle cell disease (SCD) programme at Muhimbi...

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Bibliographic Details
Main Authors: Bruno P Mmbando, Josephine Mgaya, Sharon E Cox, Siana N Mtatiro, Deogratias Soka, Stella Rwezaula, Elineema Meda, Evarist Msaki, Robert W Snow, Neal Jeffries, Nancy L Geller, Julie Makani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4428884?pdf=render

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