Basics and applications of tumor-derived extracellular vesicles
Abstract Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contr...
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doaj-4b886d35e79c4dc9a6b1bcb7bee943402020-11-25T03:00:33ZengBMCJournal of Biomedical Science1423-01272019-05-0126111710.1186/s12929-019-0533-xBasics and applications of tumor-derived extracellular vesiclesYu-Ling Tai0Pei-Yu Chu1Bao-Hong Lee2Ko-Chien Chen3Chia-Yu Yang4Wen-Hung Kuo5Tang-Long Shen6Department of Plant Pathology and Microbiology, National Taiwan UniversityDepartment of Plant Pathology and Microbiology, National Taiwan UniversityDivision of Hematology and Oncology, Department of Internal Medicine, Taipei Medical University HospitalDepartment of Plant Pathology and Microbiology, National Taiwan UniversityDepartment of Plant Pathology and Microbiology, National Taiwan UniversityDepartment of Surgery, National Taiwan University HospitalDepartment of Plant Pathology and Microbiology, National Taiwan UniversityAbstract Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contribute to drug resistance and cancer recurrence. Moreover, the molecular and functional characteristics of cancer through its development and posttreatment evolve over time. Tumor-derived EVs are profoundly involved in this process and can, therefore, provide valuable real-time information to reflect dynamic changes occurring within the body. Because they bear unique molecular profiles or signatures, tumor-derived EVs have been highlighted as valuable diagnostic and predictive biomarkers as well as novel therapeutic targets. In addition, the use of an advanced EV-based drug delivery system for cancer therapeutics has recently been emphasized in both basic and clinical studies. In this review, we highlight comprehensive aspects of tumor-derived EVs in oncogenic processes and their potential clinical applications.http://link.springer.com/article/10.1186/s12929-019-0533-xExtracellular vesiclesexosometumor-derived EVshomeostasistumor microenvironmentEV isolation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yu-Ling Tai Pei-Yu Chu Bao-Hong Lee Ko-Chien Chen Chia-Yu Yang Wen-Hung Kuo Tang-Long Shen |
spellingShingle |
Yu-Ling Tai Pei-Yu Chu Bao-Hong Lee Ko-Chien Chen Chia-Yu Yang Wen-Hung Kuo Tang-Long Shen Basics and applications of tumor-derived extracellular vesicles Journal of Biomedical Science Extracellular vesicles exosome tumor-derived EVs homeostasis tumor microenvironment EV isolation |
author_facet |
Yu-Ling Tai Pei-Yu Chu Bao-Hong Lee Ko-Chien Chen Chia-Yu Yang Wen-Hung Kuo Tang-Long Shen |
author_sort |
Yu-Ling Tai |
title |
Basics and applications of tumor-derived extracellular vesicles |
title_short |
Basics and applications of tumor-derived extracellular vesicles |
title_full |
Basics and applications of tumor-derived extracellular vesicles |
title_fullStr |
Basics and applications of tumor-derived extracellular vesicles |
title_full_unstemmed |
Basics and applications of tumor-derived extracellular vesicles |
title_sort |
basics and applications of tumor-derived extracellular vesicles |
publisher |
BMC |
series |
Journal of Biomedical Science |
issn |
1423-0127 |
publishDate |
2019-05-01 |
description |
Abstract Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contribute to drug resistance and cancer recurrence. Moreover, the molecular and functional characteristics of cancer through its development and posttreatment evolve over time. Tumor-derived EVs are profoundly involved in this process and can, therefore, provide valuable real-time information to reflect dynamic changes occurring within the body. Because they bear unique molecular profiles or signatures, tumor-derived EVs have been highlighted as valuable diagnostic and predictive biomarkers as well as novel therapeutic targets. In addition, the use of an advanced EV-based drug delivery system for cancer therapeutics has recently been emphasized in both basic and clinical studies. In this review, we highlight comprehensive aspects of tumor-derived EVs in oncogenic processes and their potential clinical applications. |
topic |
Extracellular vesicles exosome tumor-derived EVs homeostasis tumor microenvironment EV isolation |
url |
http://link.springer.com/article/10.1186/s12929-019-0533-x |
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