Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation
Aim of the study. To verify the impact of the etiology of mitral valve regurgitation on a 5-year outcome after repair and concomitant coronary artery bypass grafting (CABG). Methods. One hundred and eleven consecutive patients (mean age of 69+/-8 years) who underwent mitral valve repair, 65 for isch...
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doaj-4b94a228ed9644aea9e279aad895acde2020-11-24T22:52:08ZengGESDAVArchives of Clinical and Experimental Surgery2146-81332012-06-011312913710.5455/aces.2012041202584017247Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral RegurgitationPaolo Nardi0Antonio Pellegrino1Carlo Bassano2Fabio Bertoldo3Antonio Scafuri4Jacob Zeitani5Luigi ChiarielloCardiac Surgery Unit, Tor Vergata University of Rome, Policlinico Tor Vergata, Rome, Italy Cardiac Surgery Unit, Tor Vergata University of Rome, Policlinico Tor Vergata, Rome, Italy Cardiac Surgery Unit, Tor Vergata University of Rome, Policlinico Tor Vergata, Rome, Italy Cardiac Surgery Unit, Tor Vergata University of Rome, Policlinico Tor Vergata, Rome, Italy Cardiac Surgery Unit, Tor Vergata University of Rome, Policlinico Tor Vergata, Rome, Italy Cardiac Surgery Unit, Tor Vergata University of Rome, Policlinico Tor Vergata, Rome, ItalyAim of the study. To verify the impact of the etiology of mitral valve regurgitation on a 5-year outcome after repair and concomitant coronary artery bypass grafting (CABG). Methods. One hundred and eleven consecutive patients (mean age of 69+/-8 years) who underwent mitral valve repair, 65 for ischemic and 46 for degenerative mitral regurgitation, and concomitant CABG, were retrospectively analyzed. The mean follow-up was 40+/-28 (9-104) months. Five-year survival (including operative mortality), and survival free from events (postoperative low output syndrome, progression of mitral regurgitation, onset or worsening of congestive heart failure, recurrence of myocardial infarction, and the need for mitral valve replacement) were analyzed. Results. Compared with degenerative, ischemic mitral regurgitation was associated with a higher incidence of previous myocardial infarction (P<0.0001), left ventricular ejection fraction (LVEF) <0.45 (P<0.0001), and more diseased coronary vessels per patient (P<0.0001). Five-year all-cause mortality was 18% (20/111). Independent predictors of mortality were older age at operation (P=0.0008), LVEF<0.45 (P=0.04), and the ischemic etiology of mitral regurgitation (P=0.03). At five years, survival was 69%+/-7.6% for ischemic versus 87%+/-6.5% for degenerative etiology (P=0.03); event-free survival was 58%+/-8.4% versus 75%+/-8% (P=0.02), and freedom from late cardiac death was 85%+/-6.6% versus 100% (P=0.02). Freedom from mitral valve reoperation was 97+/-2.4%. Conclusions. Ischemic mitral regurgitation and ldquo;per se and rdquo; predicted limited survival and event-free survival. Left ventricular dysfunction is frequently associated with the ischemic etiology. An early surgical indication to prevent left ventricular dysfunction could be important to improve the mid-term outcome. [Arch Clin Exp Surg 2012; 1(3.000): 129-137]http://www.scopemed.org/fulltextpdf.php?mno=17247Mitral valve repairdegenerative mitral valve diseaseischemic mitral valve diseasecoronary artery bypass grafting surgery |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paolo Nardi Antonio Pellegrino Carlo Bassano Fabio Bertoldo Antonio Scafuri Jacob Zeitani Luigi Chiariello |
spellingShingle |
Paolo Nardi Antonio Pellegrino Carlo Bassano Fabio Bertoldo Antonio Scafuri Jacob Zeitani Luigi Chiariello Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation Archives of Clinical and Experimental Surgery Mitral valve repair degenerative mitral valve disease ischemic mitral valve disease coronary artery bypass grafting surgery |
author_facet |
Paolo Nardi Antonio Pellegrino Carlo Bassano Fabio Bertoldo Antonio Scafuri Jacob Zeitani Luigi Chiariello |
author_sort |
Paolo Nardi |
title |
Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation |
title_short |
Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation |
title_full |
Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation |
title_fullStr |
Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation |
title_full_unstemmed |
Mid-Term Outcome of Mitral Valve Repair and Coronary Artery Bypass Grafting for Ischemic or Degenerative Mitral Regurgitation |
title_sort |
mid-term outcome of mitral valve repair and coronary artery bypass grafting for ischemic or degenerative mitral regurgitation |
publisher |
GESDAV |
series |
Archives of Clinical and Experimental Surgery |
issn |
2146-8133 |
publishDate |
2012-06-01 |
description |
Aim of the study. To verify the impact of the etiology of mitral valve regurgitation on a 5-year outcome after repair and concomitant coronary artery bypass grafting (CABG).
Methods. One hundred and eleven consecutive patients (mean age of 69+/-8 years) who underwent mitral valve repair, 65 for ischemic and 46 for degenerative mitral regurgitation, and concomitant CABG, were retrospectively analyzed. The mean follow-up was 40+/-28 (9-104) months. Five-year survival (including operative mortality), and survival free from events (postoperative low output syndrome, progression of mitral regurgitation, onset or worsening of congestive heart failure, recurrence of myocardial infarction, and the need for mitral valve replacement) were analyzed.
Results. Compared with degenerative, ischemic mitral regurgitation was associated with a higher incidence of previous myocardial infarction (P<0.0001), left ventricular ejection fraction (LVEF) <0.45 (P<0.0001), and more diseased coronary vessels per patient (P<0.0001). Five-year all-cause mortality was 18% (20/111). Independent predictors of mortality were older age at operation (P=0.0008), LVEF<0.45 (P=0.04), and the ischemic etiology of mitral regurgitation (P=0.03). At five years, survival was 69%+/-7.6% for ischemic versus 87%+/-6.5% for degenerative etiology (P=0.03); event-free survival was 58%+/-8.4% versus 75%+/-8% (P=0.02), and freedom from late cardiac death was 85%+/-6.6% versus 100% (P=0.02). Freedom from mitral valve reoperation was 97+/-2.4%.
Conclusions. Ischemic mitral regurgitation and ldquo;per se and rdquo; predicted limited survival and event-free survival. Left ventricular dysfunction is frequently associated with the ischemic etiology. An early surgical indication to prevent left ventricular dysfunction could be important to improve the mid-term outcome. [Arch Clin Exp Surg 2012; 1(3.000): 129-137] |
topic |
Mitral valve repair degenerative mitral valve disease ischemic mitral valve disease coronary artery bypass grafting surgery |
url |
http://www.scopemed.org/fulltextpdf.php?mno=17247 |
work_keys_str_mv |
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