“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems
BackgroundSuicide is an unresolved psychiatric and public health emergency, claiming 800,000 lives each year, however, its neurobiological etiology is still not understood. In spite of original reports concerning the involvement of 5-HTTLPR in interaction with recent stress in the appearance of suic...
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Frontiers Media S.A.
2020-06-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00567/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Janos Bokor Sandor Krause Dora Torok Nora Eszlari Nora Eszlari Sara Sutori Sara Sutori Zsofia Gal Peter Petschner Peter Petschner Ian M. Anderson Bill Deakin Gyorgy Bagdy Gyorgy Bagdy Gyorgy Bagdy Gabriella Juhasz Gabriella Juhasz Gabriella Juhasz Xenia Gonda Xenia Gonda Xenia Gonda |
spellingShingle |
Janos Bokor Sandor Krause Dora Torok Nora Eszlari Nora Eszlari Sara Sutori Sara Sutori Zsofia Gal Peter Petschner Peter Petschner Ian M. Anderson Bill Deakin Gyorgy Bagdy Gyorgy Bagdy Gyorgy Bagdy Gabriella Juhasz Gabriella Juhasz Gabriella Juhasz Xenia Gonda Xenia Gonda Xenia Gonda “Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems Frontiers in Psychiatry suicide attempts suicidal ideation childhood adversities recent life events 5-HTTLPR |
author_facet |
Janos Bokor Sandor Krause Dora Torok Nora Eszlari Nora Eszlari Sara Sutori Sara Sutori Zsofia Gal Peter Petschner Peter Petschner Ian M. Anderson Bill Deakin Gyorgy Bagdy Gyorgy Bagdy Gyorgy Bagdy Gabriella Juhasz Gabriella Juhasz Gabriella Juhasz Xenia Gonda Xenia Gonda Xenia Gonda |
author_sort |
Janos Bokor |
title |
“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems |
title_short |
“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems |
title_full |
“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems |
title_fullStr |
“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems |
title_full_unstemmed |
“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship Problems |
title_sort |
“out, out, brief candle! life’s but a walking shadow”: 5-httlpr is associated with current suicidal ideation but not with previous suicide attempts and interacts with recent relationship problems |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2020-06-01 |
description |
BackgroundSuicide is an unresolved psychiatric and public health emergency, claiming 800,000 lives each year, however, its neurobiological etiology is still not understood. In spite of original reports concerning the involvement of 5-HTTLPR in interaction with recent stress in the appearance of suicidal ideation and attempts, replication studies have yielded contradictory results. In our study, we analyzed the association between 5-HTTLPR and lifetime suicide attempts, current suicidal ideation, hopelessness and thoughts of death as main effects, and in interaction with childhood adversities, recent stress, and different types of recent life events in a general population sample.MethodsTwo thousand and three hundred fifty-eight unrelated European volunteers were genotyped for 5-HTTLPR, provided phenotypic data on previous suicide attempts, and current suicidal ideation, hopelessness and thoughts about death, and information on childhood adversities and recent life events. Logistic and linear regression models were run with age, gender, and population as covariates to test for the effect of 5-HTTLPR as a main effect and in interaction with childhood adversities and recent life events on previous suicide attempts and current suicidal ideation. Benjamini-Hochberg FDR Q values were calculated to correct for multiple testing.Results5-HTTLPR had no significant effect on lifetime suicide attempts either as a main effect on in interaction with childhood adversities. 5-HTTLPR had a significant main effect on current suicidal ideation in the dominant model (Q=0.0344). 5-HTTLPR did not interact with childhood adversities or total number of recent life events on any phenotypes related to current suicidal risk, however, a significant interaction effect between 5-HTTLPR and current relationship problems emerged in the case of current suicidal ideation in the dominant model (Q=0.0218) and in the case of thoughts about death and dying in the dominant (Q=0.0094) and additive models (Q=0.0281).ConclusionWhile 5-HTTLPR did not influence previous suicide attempts or interacted with childhood adversities, it did influence current suicidal ideation with, in addition, an interaction with recent relationship problems supporting the involvement of 5-HTTLPR in suicide. Our findings that 5-HTTLPR impacts only certain types of suicide risk-related behaviors and that it interacts with only distinct types of recent stressors provides a possible explanation for previous conflicting findings. |
topic |
suicide attempts suicidal ideation childhood adversities recent life events 5-HTTLPR |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2020.00567/full |
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doaj-4b973a5c6b65410db45c5dc2ffd92f222020-11-25T03:55:43ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-06-011110.3389/fpsyt.2020.00567556709“Out, out, brief candle! Life’s but a walking shadow”: 5-HTTLPR Is Associated With Current Suicidal Ideation but Not With Previous Suicide Attempts and Interacts With Recent Relationship ProblemsJanos Bokor0Sandor Krause1Dora Torok2Nora Eszlari3Nora Eszlari4Sara Sutori5Sara Sutori6Zsofia Gal7Peter Petschner8Peter Petschner9Ian M. Anderson10Bill Deakin11Gyorgy Bagdy12Gyorgy Bagdy13Gyorgy Bagdy14Gabriella Juhasz15Gabriella Juhasz16Gabriella Juhasz17Xenia Gonda18Xenia Gonda19Xenia Gonda20Department of Forensic and Insurance Medicine, Semmelweis University, Budapest, HungaryNyírő Gyula National Institute of Psychiatry and Addictions, Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryNAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryFaculty of Humanity and Social Sciences, Institute of Psychology, Pazmany Peter Catholic University, Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryMTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, HungaryNeuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United KingdomNeuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, The University of Manchester and Manchester Academic Health Sciences Centre, Manchester, United KingdomDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryNAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, HungaryMTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, HungaryMTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, HungarySE-NAP-2 Genetic Brain Imaging Migraine Research Group, Semmelweis University, Budapest, HungaryNAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, HungaryMTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, HungaryDepartment of Psychiatry and Psychotherapy, Semmelweis University, Budapest, HungaryBackgroundSuicide is an unresolved psychiatric and public health emergency, claiming 800,000 lives each year, however, its neurobiological etiology is still not understood. In spite of original reports concerning the involvement of 5-HTTLPR in interaction with recent stress in the appearance of suicidal ideation and attempts, replication studies have yielded contradictory results. In our study, we analyzed the association between 5-HTTLPR and lifetime suicide attempts, current suicidal ideation, hopelessness and thoughts of death as main effects, and in interaction with childhood adversities, recent stress, and different types of recent life events in a general population sample.MethodsTwo thousand and three hundred fifty-eight unrelated European volunteers were genotyped for 5-HTTLPR, provided phenotypic data on previous suicide attempts, and current suicidal ideation, hopelessness and thoughts about death, and information on childhood adversities and recent life events. Logistic and linear regression models were run with age, gender, and population as covariates to test for the effect of 5-HTTLPR as a main effect and in interaction with childhood adversities and recent life events on previous suicide attempts and current suicidal ideation. Benjamini-Hochberg FDR Q values were calculated to correct for multiple testing.Results5-HTTLPR had no significant effect on lifetime suicide attempts either as a main effect on in interaction with childhood adversities. 5-HTTLPR had a significant main effect on current suicidal ideation in the dominant model (Q=0.0344). 5-HTTLPR did not interact with childhood adversities or total number of recent life events on any phenotypes related to current suicidal risk, however, a significant interaction effect between 5-HTTLPR and current relationship problems emerged in the case of current suicidal ideation in the dominant model (Q=0.0218) and in the case of thoughts about death and dying in the dominant (Q=0.0094) and additive models (Q=0.0281).ConclusionWhile 5-HTTLPR did not influence previous suicide attempts or interacted with childhood adversities, it did influence current suicidal ideation with, in addition, an interaction with recent relationship problems supporting the involvement of 5-HTTLPR in suicide. Our findings that 5-HTTLPR impacts only certain types of suicide risk-related behaviors and that it interacts with only distinct types of recent stressors provides a possible explanation for previous conflicting findings.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00567/fullsuicide attemptssuicidal ideationchildhood adversitiesrecent life events5-HTTLPR |