From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Abstract Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut...
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doaj-4b9b8cf7bf78422bac4226249fdc264b2021-07-25T11:08:48ZengBMCMicrobiome2049-26182021-07-019111610.1186/s40168-021-01093-yFrom gut microbiota to host appetite: gut microbiota-derived metabolites as key regulatorsHui Han0Bao Yi1Ruqing Zhong2Mengyu Wang3Shunfen Zhang4Jie Ma5Yulong Yin6Jie Yin7Liang Chen8Hongfu Zhang9State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesCollege of Animal Science and Technology, Hunan Agricultural UniversityCollege of Animal Science and Technology, Hunan Agricultural UniversityCollege of Animal Science and Technology, Hunan Agricultural UniversityState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesAbstract Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstracthttps://doi.org/10.1186/s40168-021-01093-yGut microbiotaAppetiteMetabolitesHormoneImmune |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui Han Bao Yi Ruqing Zhong Mengyu Wang Shunfen Zhang Jie Ma Yulong Yin Jie Yin Liang Chen Hongfu Zhang |
spellingShingle |
Hui Han Bao Yi Ruqing Zhong Mengyu Wang Shunfen Zhang Jie Ma Yulong Yin Jie Yin Liang Chen Hongfu Zhang From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators Microbiome Gut microbiota Appetite Metabolites Hormone Immune |
author_facet |
Hui Han Bao Yi Ruqing Zhong Mengyu Wang Shunfen Zhang Jie Ma Yulong Yin Jie Yin Liang Chen Hongfu Zhang |
author_sort |
Hui Han |
title |
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators |
title_short |
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators |
title_full |
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators |
title_fullStr |
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators |
title_full_unstemmed |
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators |
title_sort |
from gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators |
publisher |
BMC |
series |
Microbiome |
issn |
2049-2618 |
publishDate |
2021-07-01 |
description |
Abstract Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract |
topic |
Gut microbiota Appetite Metabolites Hormone Immune |
url |
https://doi.org/10.1186/s40168-021-01093-y |
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