From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

Abstract Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut...

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Main Authors: Hui Han, Bao Yi, Ruqing Zhong, Mengyu Wang, Shunfen Zhang, Jie Ma, Yulong Yin, Jie Yin, Liang Chen, Hongfu Zhang
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Microbiome
Subjects:
Gut microbiota
Appetite
Metabolites
Hormone
Immune
Online Access:https://doi.org/10.1186/s40168-021-01093-y
id doaj-4b9b8cf7bf78422bac4226249fdc264b
record_format Article
spelling doaj-4b9b8cf7bf78422bac4226249fdc264b2021-07-25T11:08:48ZengBMCMicrobiome2049-26182021-07-019111610.1186/s40168-021-01093-yFrom gut microbiota to host appetite: gut microbiota-derived metabolites as key regulatorsHui Han0Bao Yi1Ruqing Zhong2Mengyu Wang3Shunfen Zhang4Jie Ma5Yulong Yin6Jie Yin7Liang Chen8Hongfu Zhang9State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesCollege of Animal Science and Technology, Hunan Agricultural UniversityCollege of Animal Science and Technology, Hunan Agricultural UniversityCollege of Animal Science and Technology, Hunan Agricultural UniversityState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural SciencesAbstract Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstracthttps://doi.org/10.1186/s40168-021-01093-yGut microbiotaAppetiteMetabolitesHormoneImmune
collection DOAJ
language English
format Article
sources DOAJ
author Hui Han
Bao Yi
Ruqing Zhong
Mengyu Wang
Shunfen Zhang
Jie Ma
Yulong Yin
Jie Yin
Liang Chen
Hongfu Zhang
spellingShingle Hui Han
Bao Yi
Ruqing Zhong
Mengyu Wang
Shunfen Zhang
Jie Ma
Yulong Yin
Jie Yin
Liang Chen
Hongfu Zhang
From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
Microbiome
Gut microbiota
Appetite
Metabolites
Hormone
Immune
author_facet Hui Han
Bao Yi
Ruqing Zhong
Mengyu Wang
Shunfen Zhang
Jie Ma
Yulong Yin
Jie Yin
Liang Chen
Hongfu Zhang
author_sort Hui Han
title From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
title_short From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
title_full From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
title_fullStr From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
title_full_unstemmed From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
title_sort from gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators
publisher BMC
series Microbiome
issn 2049-2618
publishDate 2021-07-01
description Abstract Feelings of hunger and satiety are the key determinants for maintaining the life of humans and animals. Disturbed appetite control may disrupt the metabolic health of the host and cause various metabolic disorders. A variety of factors have been implicated in appetite control, including gut microbiota, which develop the intricate interactions to manipulate the metabolic requirements and hedonic feelings. Gut microbial metabolites and components act as appetite-related signaling molecules to regulate appetite-related hormone secretion and the immune system, or act directly on hypothalamic neurons. Herein, we summarize the effects of gut microbiota on host appetite and consider the potential molecular mechanisms. Furthermore, we propose that the manipulation of gut microbiota represents a clinical therapeutic potential for lessening the development and consequence of appetite-related disorders. Video abstract
topic Gut microbiota
Appetite
Metabolites
Hormone
Immune
url https://doi.org/10.1186/s40168-021-01093-y
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