Antigen recognition by IgG4 antibodies in human trichinellosis
The antibody isotype response to Trichinella spiralis excretory/secretory (ES) products of muscle larva was examined using sera from patients with confirmed trichinellosis. Using Western blots we identify components of the ES antigen that are recognized by IgM and IgG antibodies. A 45 kDa component...
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EDP Sciences
2001-06-01
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Online Access: | http://dx.doi.org/10.1051/parasite/200108s2168 |
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doaj-4b9d8a530f984ccaa4b1660953638e682021-02-02T01:23:10ZengEDP SciencesParasite1252-607X1776-10422001-06-018S168S17110.1051/parasite/200108s2168parasite200108s2p168Antigen recognition by IgG4 antibodies in human trichinellosisPinelli E.Van Der Lugt G.Homan W.Van Der Giessen J.Kortbeek L.M.The antibody isotype response to Trichinella spiralis excretory/secretory (ES) products of muscle larva was examined using sera from patients with confirmed trichinellosis. Using Western blots we identify components of the ES antigen that are recognized by IgM and IgG antibodies. A 45 kDa component was strongly recognized by different antibody classes and subclasses. We observed a 45 kDa-specific lgG4 response that was detected exclusively using sera of patients with trichinellosis and not of patients with echinococcosis, filariasis, cysticercosis, ascariasis, strongyloidiasis or toxocariasis. These results are relevant for the diagnosis of human trichinellosis.http://dx.doi.org/10.1051/parasite/200108s2168human trichinellosisES antigen45 kDalgG4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pinelli E. Van Der Lugt G. Homan W. Van Der Giessen J. Kortbeek L.M. |
spellingShingle |
Pinelli E. Van Der Lugt G. Homan W. Van Der Giessen J. Kortbeek L.M. Antigen recognition by IgG4 antibodies in human trichinellosis Parasite human trichinellosis ES antigen 45 kDa lgG4 |
author_facet |
Pinelli E. Van Der Lugt G. Homan W. Van Der Giessen J. Kortbeek L.M. |
author_sort |
Pinelli E. |
title |
Antigen recognition by IgG4 antibodies in human trichinellosis |
title_short |
Antigen recognition by IgG4 antibodies in human trichinellosis |
title_full |
Antigen recognition by IgG4 antibodies in human trichinellosis |
title_fullStr |
Antigen recognition by IgG4 antibodies in human trichinellosis |
title_full_unstemmed |
Antigen recognition by IgG4 antibodies in human trichinellosis |
title_sort |
antigen recognition by igg4 antibodies in human trichinellosis |
publisher |
EDP Sciences |
series |
Parasite |
issn |
1252-607X 1776-1042 |
publishDate |
2001-06-01 |
description |
The antibody isotype response to Trichinella spiralis excretory/secretory (ES) products of muscle larva was examined using sera from patients with confirmed trichinellosis. Using Western blots we identify components of the ES antigen that are recognized by IgM and IgG antibodies. A 45 kDa component was strongly recognized by different antibody classes and subclasses. We observed a 45 kDa-specific lgG4 response that was detected exclusively using sera of patients with trichinellosis and not of patients with echinococcosis, filariasis, cysticercosis, ascariasis, strongyloidiasis or toxocariasis. These results are relevant for the diagnosis of human trichinellosis. |
topic |
human trichinellosis ES antigen 45 kDa lgG4 |
url |
http://dx.doi.org/10.1051/parasite/200108s2168 |
work_keys_str_mv |
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_version_ |
1724311842317139968 |