Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index
Objectives The purpose of this study was to evaluate the metabolic pathways activated in the serum of African-American women during late pregnancy that predicted term labor dystocia. Study Design Matched case–control study (n = 97; 48 cases of term labor dystocia and 49 normal labor progr...
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Thieme Medical Publishers, Inc.
2020-01-01
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Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1702928 |
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doaj-4babe72ec4864760bc10156feb49340d2020-11-25T03:37:28ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052020-01-011001e68e7710.1055/s-0040-1702928Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass IndexNicole S. Carlson0Jennifer K. Frediani1Elizabeth J. Corwin2Anne Dunlop3Dean Jones4Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GeorgiaEmory University Nell Hodgson Woodruff School of Nursing, Atlanta, GeorgiaDepartment of Physiology, Columbia University School of Nursing, New York, New YorkDepartments of Family and Preventive Medicine, Epidemiology, and Nursing, Emory University, Atlanta, GeorgiaDivision of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University, Atlanta, GeorgiaObjectives The purpose of this study was to evaluate the metabolic pathways activated in the serum of African-American women during late pregnancy that predicted term labor dystocia. Study Design Matched case–control study (n = 97; 48 cases of term labor dystocia and 49 normal labor progression controls) with selection based on body mass index (BMI) at hospital admission and maternal age. Late pregnancy serum samples were analyzed using ultra-high-resolution metabolomics. Differentially expressed metabolic features and pathways between cases experiencing term labor dystocia and normal labor controls were evaluated in the total sample, among women who were obese at the time of labor (BMI ≥ 30 kg/m2), and among women who were not obese. Results Labor dystocia was predicted by different metabolic pathways in late pregnancy serum among obese (androgen/estrogen biosynthesis) versus nonobese African-American women (fatty acid activation, steroid hormone biosynthesis, bile acid biosynthesis, glycosphingolipid metabolism). After adjusting for maternal BMI and age in the total sample, labor dystocia was predicted by tryptophan metabolic pathways in addition to C21 steroid hormone, glycosphingolipid, and androgen/estrogen metabolism. Conclusion Metabolic pathways consistent with lipotoxicity, steroid hormone production, and tryptophan metabolism in late pregnancy serum were significantly associated with term labor dystocia in African-American women.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1702928labor dystociaobesitymechanismsmetabolomicsparturition |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nicole S. Carlson Jennifer K. Frediani Elizabeth J. Corwin Anne Dunlop Dean Jones |
spellingShingle |
Nicole S. Carlson Jennifer K. Frediani Elizabeth J. Corwin Anne Dunlop Dean Jones Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index American Journal of Perinatology Reports labor dystocia obesity mechanisms metabolomics parturition |
author_facet |
Nicole S. Carlson Jennifer K. Frediani Elizabeth J. Corwin Anne Dunlop Dean Jones |
author_sort |
Nicole S. Carlson |
title |
Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index |
title_short |
Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index |
title_full |
Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index |
title_fullStr |
Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index |
title_full_unstemmed |
Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index |
title_sort |
metabolomic pathways predicting labor dystocia by maternal body mass index |
publisher |
Thieme Medical Publishers, Inc. |
series |
American Journal of Perinatology Reports |
issn |
2157-6998 2157-7005 |
publishDate |
2020-01-01 |
description |
Objectives The purpose of this study was to evaluate the metabolic pathways activated in the serum of African-American women during late pregnancy that predicted term labor dystocia.
Study Design Matched case–control study (n = 97; 48 cases of term labor dystocia and 49 normal labor progression controls) with selection based on body mass index (BMI) at hospital admission and maternal age. Late pregnancy serum samples were analyzed using ultra-high-resolution metabolomics. Differentially expressed metabolic features and pathways between cases experiencing term labor dystocia and normal labor controls were evaluated in the total sample, among women who were obese at the time of labor (BMI ≥ 30 kg/m2), and among women who were not obese.
Results Labor dystocia was predicted by different metabolic pathways in late pregnancy serum among obese (androgen/estrogen biosynthesis) versus nonobese African-American women (fatty acid activation, steroid hormone biosynthesis, bile acid biosynthesis, glycosphingolipid metabolism). After adjusting for maternal BMI and age in the total sample, labor dystocia was predicted by tryptophan metabolic pathways in addition to C21 steroid hormone, glycosphingolipid, and androgen/estrogen metabolism.
Conclusion Metabolic pathways consistent with lipotoxicity, steroid hormone production, and tryptophan metabolism in late pregnancy serum were significantly associated with term labor dystocia in African-American women. |
topic |
labor dystocia obesity mechanisms metabolomics parturition |
url |
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1702928 |
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