Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A

Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disorders may yield new understanding about the underlying neuropathological processes and could prove essential for drug development....

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Main Authors:	Morad Kamand, Mirolyuba Ilieva, Sheena Louise Forsberg, Mads Thomassen, Åsa Fex Svenningsen, Morten Meyer, Tanja Maria Michel
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506120303391

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spelling	doaj-4bada3e3c5324088884ea6bc3d9783a92020-12-19T05:04:54ZengElsevierStem Cell Research1873-50612020-12-0149102038Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-AMorad Kamand0Mirolyuba Ilieva1Sheena Louise Forsberg2Mads Thomassen3Åsa Fex Svenningsen4Morten Meyer5Tanja Maria Michel6Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark; Corresponding authors at: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark (M. Kamand). Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark (T.M. Michel).Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, DenmarkDepartment of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, DenmarkDepartment of Clinical Research, Department of Human Genetics, Odense University Hospital, DenmarkDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Brain Research - Inter Disciplinary Guided Excellence (BRIDGE), Odense, DenmarkDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Brain Research - Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Department of Neurology, Odense University Hospital, DenmarkDepartment of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark; Brain Research - Inter Disciplinary Guided Excellence (BRIDGE), Odense, Denmark; Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark; Corresponding authors at: Department of Clinical Research, Department of Psychiatry, University of Southern Denmark, Odense, Denmark (M. Kamand). Psychiatry in the Region of Southern Denmark, Odense University Hospital, Denmark (T.M. Michel).Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disorders may yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a new human induced pluripotent stem cell (iPSC) line (SDUKIi004-A) generated from skin fibroblasts derived from a 21-year old male patient diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) (“FYNEN-cohort”). Reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.http://www.sciencedirect.com/science/article/pii/S1873506120303391
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Morad Kamand Mirolyuba Ilieva Sheena Louise Forsberg Mads Thomassen Åsa Fex Svenningsen Morten Meyer Tanja Maria Michel
spellingShingle	Morad Kamand Mirolyuba Ilieva Sheena Louise Forsberg Mads Thomassen Åsa Fex Svenningsen Morten Meyer Tanja Maria Michel Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A Stem Cell Research
author_facet	Morad Kamand Mirolyuba Ilieva Sheena Louise Forsberg Mads Thomassen Åsa Fex Svenningsen Morten Meyer Tanja Maria Michel
author_sort	Morad Kamand
title	Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A
title_short	Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A
title_full	Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A
title_fullStr	Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A
title_full_unstemmed	Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A
title_sort	generation of autism spectrum disorder patient-derived ipsc line sdukii004-a
publisher	Elsevier
series	Stem Cell Research
issn	1873-5061
publishDate	2020-12-01
description	Autism is a heterogeneous neurodevelopmental disorder defined by deficits in socialization, communication, and patterns of behavior. Using stem cells to model brain disorders may yield new understanding about the underlying neuropathological processes and could prove essential for drug development. We present here a new human induced pluripotent stem cell (iPSC) line (SDUKIi004-A) generated from skin fibroblasts derived from a 21-year old male patient diagnosed with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) (“FYNEN-cohort”). Reprogramming of the fibroblasts was accomplished using integration-free episomal plasmids. Characterization validated the expression of pluripotency markers, differentiation into the three germ layers, and absence of chromosomal abnormalities.
url	http://www.sciencedirect.com/science/article/pii/S1873506120303391
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Generation of autism spectrum disorder patient-derived iPSC line SDUKIi004-A

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