Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after...
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2017-08-01
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doaj-4bc09502862a4a3a98f165d9856f4c782020-12-08T02:36:08ZengNature Publishing GroupScientific Reports2045-23222017-08-017111210.1038/s41598-017-09536-zAltered Lipid Metabolism in Recovered SARS Patients Twelve Years after InfectionQi Wu0Lina Zhou1Xin Sun2Zhongfang Yan3Chunxiu Hu4Junping Wu5Long Xu6Xue Li7Huiling Liu8Peiyuan Yin9Kuan Li10Jieyu Zhao11Yanli Li12Xiaolin Wang13Yu Li14Qiuyang Zhang15Guowang Xu16Huaiyong Chen17Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical UniversityCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesDepartment of Respiratory Medicine, Tianjin Haihe HospitalDepartment of Nutrition, Tianjin Haihe HospitalCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesDepartment of Respiratory Medicine, Tianjin Haihe HospitalDepartment of Respiratory Medicine, Tianjin Haihe HospitalDepartment of Basic Medicine, Tianjin Haihe HospitalDepartment of Gastroenterology, Tianjin Haihe HospitalCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesDepartment of Basic Medicine, Tianjin Haihe HospitalCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesDepartment of Basic Medicine, Tianjin Haihe HospitalDepartment of Basic Medicine, Tianjin Haihe HospitalCAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of SciencesKey Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical UniversityAbstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.https://doi.org/10.1038/s41598-017-09536-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qi Wu Lina Zhou Xin Sun Zhongfang Yan Chunxiu Hu Junping Wu Long Xu Xue Li Huiling Liu Peiyuan Yin Kuan Li Jieyu Zhao Yanli Li Xiaolin Wang Yu Li Qiuyang Zhang Guowang Xu Huaiyong Chen |
spellingShingle |
Qi Wu Lina Zhou Xin Sun Zhongfang Yan Chunxiu Hu Junping Wu Long Xu Xue Li Huiling Liu Peiyuan Yin Kuan Li Jieyu Zhao Yanli Li Xiaolin Wang Yu Li Qiuyang Zhang Guowang Xu Huaiyong Chen Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection Scientific Reports |
author_facet |
Qi Wu Lina Zhou Xin Sun Zhongfang Yan Chunxiu Hu Junping Wu Long Xu Xue Li Huiling Liu Peiyuan Yin Kuan Li Jieyu Zhao Yanli Li Xiaolin Wang Yu Li Qiuyang Zhang Guowang Xu Huaiyong Chen |
author_sort |
Qi Wu |
title |
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection |
title_short |
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection |
title_full |
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection |
title_fullStr |
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection |
title_full_unstemmed |
Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection |
title_sort |
altered lipid metabolism in recovered sars patients twelve years after infection |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-08-01 |
description |
Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments. |
url |
https://doi.org/10.1038/s41598-017-09536-z |
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