Isolated pulmonary embolism in a patient with progestin intrauterine device and factor V Leiden

• Main Author: Soluny Jean
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2019-05-01
• Series: Journal of Community Hospital Internal Medicine Perspectives
• Subjects: Factor V Leiden; pulmonary embolism; progestin-only contraception; copper IUD; progestin IUD; venous thromboembolism
• Online Access: http://dx.doi.org/10.1080/20009666.2019.1601059

The risk of venous thromboembolism (VTE) in patients using estrogen contraception is well known. However, the association of progestin-only contraception (POC) and the risk of thrombosis is poorly investigated. Few studies on this topic have failed to prove a significant increase in VTE in patients using POC, including patients with a medical condition associated with an increased risk of thrombosis. Therefore, no specific consideration is warranted when using a POC in healthy young females, regardless of an inherited thrombophilia. We present a case of a young woman who has Factor V Leiden (FVL), presenting with an isolated pulmonary embolism (PE) while using a progesterone containing intrauterine device (IUD). The risk of VTE in FVL carriers seems to outweigh the benefit of contraception even when using progestin-only contraception. Therefore, non-hormonal contraception, such as copper IUD, seems to be the only safe alternative for contraception in this population. Further studies are needed to elucidate this observation. Abbreviation: PE: pulmonary embolism; FVL: factor V Leiden; VTE: venous thromboembolism; POC: progestin only contraception; CBC: complete blood count; CMP: complete metabolic panel; ABG: arterial Blood gas; CTPA: CT pulmonary angiography