53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in which mitosis is consistently disturbed by ce...
Main Authors: | Chii Shyang Fong, Gregory Mazo, Tuhin Das, Joshua Goodman, Minhee Kim, Brian P O'Rourke, Denisse Izquierdo, Meng-Fu Bryan Tsou |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/16270 |
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