Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)
Lanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configuration of their macrolactone ring was assigned base...
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doaj-4bcf0dfe4308475d95a6525eef156f4e2021-02-02T08:27:52ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972018-06-011411554156210.3762/bjoc.14.1321860-5397-14-132Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)Lucky S. Mulwa0Rolf Jansen1Dimas F. Praditya2Kathrin I. Mohr3Patrick W. Okanya4Joachim Wink5Eike Steinmann6Marc Stadler7Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, GermanyDepartment of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, GermanyTWINCORE-Centre for Experimental and Clinical Infection Research (Institute of Experimental Virology) Hannover. Feodor-Lynen-Str. 7–9, 30625 Hannover, Germany. Tel: +49(0)511-220027-133Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, GermanyDepartment of Biochemistry and Biotechnology, The Technical University of Kenya, P.O. Box 52428 – 00200, Located along Haile Selassie Avenue, Nairobi, Kenya. Tel: +254(020) 2219929Work group Microbial Strain Collection (MISG), Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, GermanyTWINCORE-Centre for Experimental and Clinical Infection Research (Institute of Experimental Virology) Hannover. Feodor-Lynen-Str. 7–9, 30625 Hannover, Germany. Tel: +49(0)511-220027-133Department of Microbial Drugs, Helmholtz Centre for Infection Research and German Centre for Infection Research (DZIF), partner site Hannover/Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, GermanyLanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configuration of their macrolactone ring was assigned based on NOE and vicinal 1H NMR coupling constants and by calculation of a 3D model. Lanyamycin inhibited HCV infection into mammalian liver cells with an IC50 value of 11.8 µM, and exhibited a moderate cytotoxic activity against the mouse fibroblast cell line L929 and the human nasopharyngeal cell line KB3 with IC50 values of 3.1 and 1.5 μM, respectively, and also suppressed the growth of the Gram-positive bacterium Micrococcus luteus.https://doi.org/10.3762/bjoc.14.132antimicrobialHCVlanyamycinmacrolideSorangium cellulosum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lucky S. Mulwa Rolf Jansen Dimas F. Praditya Kathrin I. Mohr Patrick W. Okanya Joachim Wink Eike Steinmann Marc Stadler |
spellingShingle |
Lucky S. Mulwa Rolf Jansen Dimas F. Praditya Kathrin I. Mohr Patrick W. Okanya Joachim Wink Eike Steinmann Marc Stadler Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria) Beilstein Journal of Organic Chemistry antimicrobial HCV lanyamycin macrolide Sorangium cellulosum |
author_facet |
Lucky S. Mulwa Rolf Jansen Dimas F. Praditya Kathrin I. Mohr Patrick W. Okanya Joachim Wink Eike Steinmann Marc Stadler |
author_sort |
Lucky S. Mulwa |
title |
Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria) |
title_short |
Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria) |
title_full |
Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria) |
title_fullStr |
Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria) |
title_full_unstemmed |
Lanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria) |
title_sort |
lanyamycin, a macrolide antibiotic from sorangium cellulosum, strain soce 481 (myxobacteria) |
publisher |
Beilstein-Institut |
series |
Beilstein Journal of Organic Chemistry |
issn |
1860-5397 |
publishDate |
2018-06-01 |
description |
Lanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configuration of their macrolactone ring was assigned based on NOE and vicinal 1H NMR coupling constants and by calculation of a 3D model. Lanyamycin inhibited HCV infection into mammalian liver cells with an IC50 value of 11.8 µM, and exhibited a moderate cytotoxic activity against the mouse fibroblast cell line L929 and the human nasopharyngeal cell line KB3 with IC50 values of 3.1 and 1.5 μM, respectively, and also suppressed the growth of the Gram-positive bacterium Micrococcus luteus. |
topic |
antimicrobial HCV lanyamycin macrolide Sorangium cellulosum |
url |
https://doi.org/10.3762/bjoc.14.132 |
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