SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation
T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20786-w |
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doaj-4bda70b629c6463d811f40ab5ed689ce2021-01-24T12:11:28ZengNature Publishing GroupNature Communications2041-17232021-01-0112111810.1038/s41467-020-20786-wSOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiationYi Tian0Chao Han1Zhiyuan Wei2Hui Dong3Xiaohe Shen4Yiqiang Cui5Xiaolan Fu6Zhiqiang Tian7Shufeng Wang8Jian Zhou9Di Yang10Yi Sun11Jizhao Yuan12Bing Ni13Yuzhang Wu14Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Department of Microbiology and Immunology, Shanxi Medical UniversityDepartment of Histology and Embryology, Nanjing Medical UniversityInstitute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)The First Affiliated Hospital of Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)Department of Pathophysiology, Third Military Medical University (Army Medical University)Institute of Immunology, PLA, Third Military Medical University (Army Medical University)T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt promoter and thereby modulation of RORγt expression.https://doi.org/10.1038/s41467-020-20786-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Yi Tian Chao Han Zhiyuan Wei Hui Dong Xiaohe Shen Yiqiang Cui Xiaolan Fu Zhiqiang Tian Shufeng Wang Jian Zhou Di Yang Yi Sun Jizhao Yuan Bing Ni Yuzhang Wu |
| spellingShingle |
Yi Tian Chao Han Zhiyuan Wei Hui Dong Xiaohe Shen Yiqiang Cui Xiaolan Fu Zhiqiang Tian Shufeng Wang Jian Zhou Di Yang Yi Sun Jizhao Yuan Bing Ni Yuzhang Wu SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation Nature Communications |
| author_facet |
Yi Tian Chao Han Zhiyuan Wei Hui Dong Xiaohe Shen Yiqiang Cui Xiaolan Fu Zhiqiang Tian Shufeng Wang Jian Zhou Di Yang Yi Sun Jizhao Yuan Bing Ni Yuzhang Wu |
| author_sort |
Yi Tian |
| title |
SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation |
| title_short |
SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation |
| title_full |
SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation |
| title_fullStr |
SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation |
| title_full_unstemmed |
SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation |
| title_sort |
sox-5 activates a novel rorγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting th17 cell differentiation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
T helper 17 (Th17) cells are important mediators of inflammatory diseases and fungal infection protection, and are critically regulated by the transcription factor (TF), RORγt. Here the authors identify a new enhancer for RORγt, RORCE2, which synergizes with another TF, Sox5, for binding with RORγt promoter and thereby modulation of RORγt expression. |
| url |
https://doi.org/10.1038/s41467-020-20786-w |
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