Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol

Estrogen Receptor Beta-Mediated Modulation of Lung Cancer Cell Proliferation by 27-Hydroxycholesterol

27-hydroxycholesterol (27HC) is an abundant cholesterol metabolite in human circulation and promotes breast cancer cell proliferation. Although lung is one of the organs that contain high levels of 27HC, the role of 27HC in lung is unknown. In this study, we found that 27HC promotes lung cancer cell...

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Bibliographic Details
Main Authors: Shiro Hiramitsu, Tomonori Ishikawa, Wan-Ru Lee, Tamor Khan, Christine Crumbley, Nimra Khwaja, Faezeh Zamanian, Arvand Asghari, Mehmet Sen, Yang Zhang, John R. Hawse, John D. Minna, Michihisa Umetani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Endocrinology
Subjects:
lung cancer
estrogen receptor
ERβ
27-hydroxycholesterol
cholesterol metabolites
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00470/full

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