Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma
Abstract Background The solute carrier (SLC) 7 family genes comprise 14 members and function as cationic amino acid/glycoprotein transporters in many cells, they are essential for the maintenance of amino acid nutrition and survival of tumor cells. This study was conducted to analyze the association...
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doaj-4bf8dcfb4f904e11971e2422388a86462020-11-25T02:09:57ZengBMCWorld Journal of Surgical Oncology1477-78192018-12-011611710.1186/s12957-018-1535-yUpregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinomaLei Shen0Chunhua Qian1Huimin Cao2Zhongrui Wang3Tingxian Luo4Chunli Liang5Department of Thyroid Breast Oncology, Shanghai East Hospital, School of Medicine, Tongji University School of MedicineDepartment of Endocrinolgy and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Thyroid and Breast, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Thyroid Breast Oncology, Shanghai East Hospital, School of Medicine, Tongji University School of MedicineDepartment of Thyroid Breast Oncology, Shanghai East Hospital, School of Medicine, Tongji University School of MedicineDepartment of Thyroid Breast Oncology, Shanghai East Hospital, School of Medicine, Tongji University School of MedicineAbstract Background The solute carrier (SLC) 7 family genes comprise 14 members and function as cationic amino acid/glycoprotein transporters in many cells, they are essential for the maintenance of amino acid nutrition and survival of tumor cells. This study was conducted to analyze the associations of SLC7 family gene expression with mortality in papillary thyroid carcinoma (PTC). Methods Clinical features, somatic mutations, and SLC7 family gene expression data were downloaded from The Cancer Genome Atlas database. Linear regression model analysis was performed to analyze the correlations between SLC7 family gene expression and clinicopathologic features. Kaplan-Meier survival and logistic regression analyses were performed to characterize the associations between gene expression and patients’ overall survival. Results Patient mortality was negatively associated with age and tumor size but positively increased cancer stage and absence of thyroiditis in PTC patients. Kaplan-Meier survival analysis indicated that patients with high SLC7A3, SLC7A5, and SLC7A11 expression levels exhibited poorer survival than those with low SLC7A3, SLC7A5, and SLC7A11 expression levels (P < 0.05 for all cases). Logistic regression analysis showed that SLC7A3, SLC7A5, and SLC7A11 were associated with increased mortality (odds ratio [OR] 8.61, 95% confidence interval [CI] 2.3–55.91; OR 3.87, 95% CI 1.18–17.31; and OR 3.87, 95% CI 1.18–17.31, respectively. Conclusion Upregulation of SLC7A3, SLC7A5, and SLC7A11 expression was associated with poor prognosis in PTC patients, and SLC7 gene expression levels are potentially useful prognostic biomarkers.http://link.springer.com/article/10.1186/s12957-018-1535-yPTCSLC7A3SLC7A5SLC7A11Overall survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Shen Chunhua Qian Huimin Cao Zhongrui Wang Tingxian Luo Chunli Liang |
spellingShingle |
Lei Shen Chunhua Qian Huimin Cao Zhongrui Wang Tingxian Luo Chunli Liang Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma World Journal of Surgical Oncology PTC SLC7A3 SLC7A5 SLC7A11 Overall survival |
author_facet |
Lei Shen Chunhua Qian Huimin Cao Zhongrui Wang Tingxian Luo Chunli Liang |
author_sort |
Lei Shen |
title |
Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma |
title_short |
Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma |
title_full |
Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma |
title_fullStr |
Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma |
title_full_unstemmed |
Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma |
title_sort |
upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2018-12-01 |
description |
Abstract Background The solute carrier (SLC) 7 family genes comprise 14 members and function as cationic amino acid/glycoprotein transporters in many cells, they are essential for the maintenance of amino acid nutrition and survival of tumor cells. This study was conducted to analyze the associations of SLC7 family gene expression with mortality in papillary thyroid carcinoma (PTC). Methods Clinical features, somatic mutations, and SLC7 family gene expression data were downloaded from The Cancer Genome Atlas database. Linear regression model analysis was performed to analyze the correlations between SLC7 family gene expression and clinicopathologic features. Kaplan-Meier survival and logistic regression analyses were performed to characterize the associations between gene expression and patients’ overall survival. Results Patient mortality was negatively associated with age and tumor size but positively increased cancer stage and absence of thyroiditis in PTC patients. Kaplan-Meier survival analysis indicated that patients with high SLC7A3, SLC7A5, and SLC7A11 expression levels exhibited poorer survival than those with low SLC7A3, SLC7A5, and SLC7A11 expression levels (P < 0.05 for all cases). Logistic regression analysis showed that SLC7A3, SLC7A5, and SLC7A11 were associated with increased mortality (odds ratio [OR] 8.61, 95% confidence interval [CI] 2.3–55.91; OR 3.87, 95% CI 1.18–17.31; and OR 3.87, 95% CI 1.18–17.31, respectively. Conclusion Upregulation of SLC7A3, SLC7A5, and SLC7A11 expression was associated with poor prognosis in PTC patients, and SLC7 gene expression levels are potentially useful prognostic biomarkers. |
topic |
PTC SLC7A3 SLC7A5 SLC7A11 Overall survival |
url |
http://link.springer.com/article/10.1186/s12957-018-1535-y |
work_keys_str_mv |
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