Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database
Natural products (NPs), biomolecules produced by living organisms, inspire the pharmaceutical industry and research due to their structural characteristics and the substituents from which they derive their activities. Glycosidic residues are frequently present in NP structures and have particular ph...
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doaj-4c00974f39b9451ca450a34a34ca984f2021-03-25T00:02:33ZengMDPI AGBiomolecules2218-273X2021-03-011148648610.3390/biom11040486Description and Analysis of Glycosidic Residues in the Largest Open Natural Products DatabaseJonas Schaub0Achim Zielesny1Christoph Steinbeck2Maria Sorokina3Institute for Inorganic and Analytical Chemistry, Friedrich-Schiller University, Lessing Strasse 8, 07743 Jena, GermanyInstitute for Bioinformatics and Chemoinformatics, Westphalian University of Applied Sciences, August-Schmidt-Ring 10, 45665 Recklinghausen, GermanyInstitute for Inorganic and Analytical Chemistry, Friedrich-Schiller University, Lessing Strasse 8, 07743 Jena, GermanyInstitute for Inorganic and Analytical Chemistry, Friedrich-Schiller University, Lessing Strasse 8, 07743 Jena, GermanyNatural products (NPs), biomolecules produced by living organisms, inspire the pharmaceutical industry and research due to their structural characteristics and the substituents from which they derive their activities. Glycosidic residues are frequently present in NP structures and have particular pharmacokinetic and pharmacodynamic importance as they improve their solubility and are often involved in molecular transport, target specificity, ligand–target interactions, and receptor binding. The COlleCtion of Open Natural prodUcTs (COCONUT) is currently the largest open database of NPs, and therefore a suitable starting point for the detection and analysis of the diversity of glycosidic residues in NPs. In this work, we report and describe the presence of circular, linear, terminal, and non-terminal glycosidic units in NPs, together with their importance in drug discovery.https://www.mdpi.com/2218-273X/11/4/486natural productsglycosidesbioactivityglycosidic residuessugarscarbohydrates |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonas Schaub Achim Zielesny Christoph Steinbeck Maria Sorokina |
spellingShingle |
Jonas Schaub Achim Zielesny Christoph Steinbeck Maria Sorokina Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database Biomolecules natural products glycosides bioactivity glycosidic residues sugars carbohydrates |
author_facet |
Jonas Schaub Achim Zielesny Christoph Steinbeck Maria Sorokina |
author_sort |
Jonas Schaub |
title |
Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database |
title_short |
Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database |
title_full |
Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database |
title_fullStr |
Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database |
title_full_unstemmed |
Description and Analysis of Glycosidic Residues in the Largest Open Natural Products Database |
title_sort |
description and analysis of glycosidic residues in the largest open natural products database |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-03-01 |
description |
Natural products (NPs), biomolecules produced by living organisms, inspire the pharmaceutical industry and research due to their structural characteristics and the substituents from which they derive their activities. Glycosidic residues are frequently present in NP structures and have particular pharmacokinetic and pharmacodynamic importance as they improve their solubility and are often involved in molecular transport, target specificity, ligand–target interactions, and receptor binding. The COlleCtion of Open Natural prodUcTs (COCONUT) is currently the largest open database of NPs, and therefore a suitable starting point for the detection and analysis of the diversity of glycosidic residues in NPs. In this work, we report and describe the presence of circular, linear, terminal, and non-terminal glycosidic units in NPs, together with their importance in drug discovery. |
topic |
natural products glycosides bioactivity glycosidic residues sugars carbohydrates |
url |
https://www.mdpi.com/2218-273X/11/4/486 |
work_keys_str_mv |
AT jonasschaub descriptionandanalysisofglycosidicresiduesinthelargestopennaturalproductsdatabase AT achimzielesny descriptionandanalysisofglycosidicresiduesinthelargestopennaturalproductsdatabase AT christophsteinbeck descriptionandanalysisofglycosidicresiduesinthelargestopennaturalproductsdatabase AT mariasorokina descriptionandanalysisofglycosidicresiduesinthelargestopennaturalproductsdatabase |
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