HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen.
In B-Chronic Lymphocytic Leukemia (B-CLL) kinase Lyn is overexpressed, active, abnormally distributed, and part of a cytosolic complex involving hematopoietic lineage cell-specific protein 1 (HS1). These aberrant properties of Lyn could partially explain leukemic cells' defective apoptosis, dir...
Main Authors: | Federica Frezzato, Cristina Gattazzo, Veronica Martini, Valentina Trimarco, Antonella Teramo, Samuela Carraro, Anna Cabrelle, Elisa Ave, Monica Facco, Renato Zambello, Elena Tibaldi, Anna Maria Brunati, Gianpietro Semenzato, Livio Trentin |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22768161/?tool=EBI |
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