Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

Objective: The liver is a central target organ of growth hormone (GH), which stimulates the synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways. A systematic multi-omics analysis of GH effects in the liver has not been performed. GH receptor (GHR) deficiency is...

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Bibliographic Details
Main Authors: Evamaria O. Riedel, Arne Hinrichs, Elisabeth Kemter, Maik Dahlhoff, Mattias Backman, Birgit Rathkolb, Cornelia Prehn, Jerzy Adamski, Simone Renner, Andreas Blutke, Martin Hrabĕ de Angelis, Martin Bidlingmaier, Jochen Schopohl, Georg J. Arnold, Thomas Fröhlich, Eckhard Wolf
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Metabolism
Subjects:
Liver
Growth hormone
Laron syndrome
Pig model
Proteomics
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300521

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