Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.
The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures wer...
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MDPI AG
2016-09-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/9/1130 |
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doaj-4c1b68c8808e46079a9107316168cd0a2020-11-24T22:30:40ZengMDPI AGMolecules1420-30492016-09-01219113010.3390/molecules21091130molecules21091130Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L.Long Zhang0Guanjun Tao1Jie Chen2Zong-Ping Zheng3State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, ChinaThe twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents.http://www.mdpi.com/1420-3049/21/9/1130Morus albatwigsphenolic compoundstyrosinase inhibition |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Long Zhang Guanjun Tao Jie Chen Zong-Ping Zheng |
| spellingShingle |
Long Zhang Guanjun Tao Jie Chen Zong-Ping Zheng Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. Molecules Morus alba twigs phenolic compounds tyrosinase inhibition |
| author_facet |
Long Zhang Guanjun Tao Jie Chen Zong-Ping Zheng |
| author_sort |
Long Zhang |
| title |
Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. |
| title_short |
Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. |
| title_full |
Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. |
| title_fullStr |
Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. |
| title_full_unstemmed |
Characterization of a New Flavone and Tyrosinase Inhibition Constituents from the Twigs of Morus alba L. |
| title_sort |
characterization of a new flavone and tyrosinase inhibition constituents from the twigs of morus alba l. |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2016-09-01 |
| description |
The twigs of Morus alba L. were found to show strong tyrosinase inhibition activity, and the responsible active components in the extract were further investigated in this study. A flavone, named morusone (1), and sixteen known compounds 2–17 were isolated from M. alba twigs and their structures were identified by interpretation of the corresponding ESI-MS and NMR spectral data. In the tyrosinase inhibitory test, the compounds steppogenin (IC50 0.98 ± 0.01 µM), 2,4,2′,4′-tetrahydroxychalcone (IC50 0.07 ± 0.02 µM), morachalcone A (IC50 0.08 ± 0.02 µM), oxyresveratrol (IC50 0.10 ± 0.01 µM), and moracin M (8.00 ± 0.22 µM) exhibited significant tyrosinase inhibition activities, much stronger than that of the positive control kojic acid. These results suggest that M. alba twig extract should served as a good source of natural tyrosinase inhibitors for use in foods as antibrowning agents or in cosmetics as skin-whitening agents. |
| topic |
Morus alba twigs phenolic compounds tyrosinase inhibition |
| url |
http://www.mdpi.com/1420-3049/21/9/1130 |
| work_keys_str_mv |
AT longzhang characterizationofanewflavoneandtyrosinaseinhibitionconstituentsfromthetwigsofmorusalbal AT guanjuntao characterizationofanewflavoneandtyrosinaseinhibitionconstituentsfromthetwigsofmorusalbal AT jiechen characterizationofanewflavoneandtyrosinaseinhibitionconstituentsfromthetwigsofmorusalbal AT zongpingzheng characterizationofanewflavoneandtyrosinaseinhibitionconstituentsfromthetwigsofmorusalbal |
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