Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets
Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions and manipulations. To date, hundreds of xeno-miRNAs have been reported in different hosts a...
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doaj-4c245f94713d4cb784921db1efb148d22020-11-25T01:03:50ZengPeerJ Inc.PeerJ2167-83592018-09-016e565010.7717/peerj.5650Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targetsYannan Fan0Maria Habib1Jianguo Xia2Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec, CanadaDepartment of Animal Science, McGill University, Ste. Anne de Bellevue, Quebec, CanadaInstitute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec, CanadaXeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions and manipulations. To date, hundreds of xeno-miRNAs have been reported in different hosts at various abundance levels. Based on computational predictions, many more miRNAs could be potentially transferred to human circulation system. There is a clear need for bioinformatics resources and tools dedicated to xeno-miRNA annotations and their potential functions. To address this need, we have systematically curated xeno-miRNAs from multiple sources, performed target predictions using well-established algorithms, and developed a user-friendly web-based tool—Xeno-miRNet—to allow researchers to search and explore xeno-miRNAs and their potential targets within different host species. Xeno-miRNet currently contains 1,702 (including both detected and predicted) xeno-miRNAs from 54 species and 98,053 potential gene targets in six hosts. The web application is freely available at http://xeno.mirnet.ca.https://peerj.com/articles/5650.pdfXeno-miRNANetwork analysismiRNACross-species communicationExosome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yannan Fan Maria Habib Jianguo Xia |
spellingShingle |
Yannan Fan Maria Habib Jianguo Xia Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets PeerJ Xeno-miRNA Network analysis miRNA Cross-species communication Exosome |
author_facet |
Yannan Fan Maria Habib Jianguo Xia |
author_sort |
Yannan Fan |
title |
Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets |
title_short |
Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets |
title_full |
Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets |
title_fullStr |
Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets |
title_full_unstemmed |
Xeno-miRNet: a comprehensive database and analytics platform to explore xeno-miRNAs and their potential targets |
title_sort |
xeno-mirnet: a comprehensive database and analytics platform to explore xeno-mirnas and their potential targets |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2018-09-01 |
description |
Xeno-miRNAs are microRNAs originating from exogenous species detected in host biofluids. A growing number of studies have suggested that many of these xeno-miRNAs may be involved in cross-species interactions and manipulations. To date, hundreds of xeno-miRNAs have been reported in different hosts at various abundance levels. Based on computational predictions, many more miRNAs could be potentially transferred to human circulation system. There is a clear need for bioinformatics resources and tools dedicated to xeno-miRNA annotations and their potential functions. To address this need, we have systematically curated xeno-miRNAs from multiple sources, performed target predictions using well-established algorithms, and developed a user-friendly web-based tool—Xeno-miRNet—to allow researchers to search and explore xeno-miRNAs and their potential targets within different host species. Xeno-miRNet currently contains 1,702 (including both detected and predicted) xeno-miRNAs from 54 species and 98,053 potential gene targets in six hosts. The web application is freely available at http://xeno.mirnet.ca. |
topic |
Xeno-miRNA Network analysis miRNA Cross-species communication Exosome |
url |
https://peerj.com/articles/5650.pdf |
work_keys_str_mv |
AT yannanfan xenomirnetacomprehensivedatabaseandanalyticsplatformtoexplorexenomirnasandtheirpotentialtargets AT mariahabib xenomirnetacomprehensivedatabaseandanalyticsplatformtoexplorexenomirnasandtheirpotentialtargets AT jianguoxia xenomirnetacomprehensivedatabaseandanalyticsplatformtoexplorexenomirnasandtheirpotentialtargets |
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