Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography
Microtubules are dynamic tubulin polymers which elongate by addition of bent guanosine triphosphate tubulin to the tips of curving protofilaments. Here authors use Brownian dynamics modeling and electron cryotomography to show that the lateral activation energy barrier in tubulin-tubulin interaction...
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Bibliographic Details
Main Authors: |
Nikita B. Gudimchuk,
Evgeni V. Ulyanov,
Eileen O’Toole,
Cynthia L. Page,
Dmitrii S. Vinogradov,
Garry Morgan,
Gabriella Li,
Jeffrey K. Moore,
Ewa Szczesna,
Antonina Roll-Mecak,
Fazoil I. Ataullakhanov,
J. Richard McIntosh |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2020-07-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-020-17553-2
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