Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review.
While generalized cerebral atrophy and neurodegenerative change following traumatic brain injury (TBI) is well recognized in adults, it remains comparatively understudied in the pediatric population, suggesting that research should address the potential for neurodegenerative change in children and y...
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doaj-4c2e2030680a4893b5599b18b5bd56602020-11-25T02:02:49ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612014-03-01810.3389/fnhum.2014.0013936212Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review.Michelle eKeightley0Michelle eKeightley1Katia eSinopoli2Katia eSinopoli3Karen eDavis4Karen eDavis5Robin eGreen6Robin eGreen7David eMikulis8David eMikulis9Richard eWennberg10Richard eWennberg11Carmela eTartaglia12Carmela eTartaglia13Jen-Kai eChen14Jen-Kai eChen15Charles eTator16Charles eTator17Holland Bloorview Kids Rehabilitation HospitalUniversity of TorontoSickkids Hospital for Sick ChildrenUniversity of TorontoToronto Western Hospital, University Health NetworkUniversity of TorontoToronto Rehabilitation Institute, University Health NetworkUniversity of TorontoToronto Western Hospital, University Health NetworkUniversity of TorontoToronto Western Hospital, University Health NetworkUniversity of TorontoToronto Western Hospital, University Health NetworkUniversity of TorontoHolland Bloorview Kids Rehabilitation HospitalMontreal Neurological InstituteToronto Western Hospital, University Health NetworkUniversity of TorontoWhile generalized cerebral atrophy and neurodegenerative change following traumatic brain injury (TBI) is well recognized in adults, it remains comparatively understudied in the pediatric population, suggesting that research should address the potential for neurodegenerative change in children and youth following TBI. This focused review examines original research findings documenting evidence for neurodegenerative change following TBI of all severities in children and youth. Our relevant inclusion and exclusion criteria identified a total of 16 articles for review. Taken together, the studies reviewed suggest there is evidence for long-term neurodegenerative change following TBI in children and youth. In particular both cross-sectional and longitudinal studies revealed volume loss in selected brain regions including the hippocampus, amygdala, globus pallidus, thalamus, periventricular white matter, cerebellum and brain stem as well as overall decreased whole brain volume and increased CSF and ventricular space. Diffusion Tensor Imaging (DTI) studies also report evidence for decreased cellular integrity, particularly in the corpus callosum. Sensitivity of the hippocampus and deep limbic structures in pediatric populations are similar to findings in the adult literature and we consider the data supporting these changes as well as the need to investigate the possibility of neurodegenerative onset in childhood associated with mTBI.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00139/fullTraumatic Brain Injuryneurodegenerationpediatricchronic traumatic encephalopathymagnetic resonance imaging. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michelle eKeightley Michelle eKeightley Katia eSinopoli Katia eSinopoli Karen eDavis Karen eDavis Robin eGreen Robin eGreen David eMikulis David eMikulis Richard eWennberg Richard eWennberg Carmela eTartaglia Carmela eTartaglia Jen-Kai eChen Jen-Kai eChen Charles eTator Charles eTator |
spellingShingle |
Michelle eKeightley Michelle eKeightley Katia eSinopoli Katia eSinopoli Karen eDavis Karen eDavis Robin eGreen Robin eGreen David eMikulis David eMikulis Richard eWennberg Richard eWennberg Carmela eTartaglia Carmela eTartaglia Jen-Kai eChen Jen-Kai eChen Charles eTator Charles eTator Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. Frontiers in Human Neuroscience Traumatic Brain Injury neurodegeneration pediatric chronic traumatic encephalopathy magnetic resonance imaging. |
author_facet |
Michelle eKeightley Michelle eKeightley Katia eSinopoli Katia eSinopoli Karen eDavis Karen eDavis Robin eGreen Robin eGreen David eMikulis David eMikulis Richard eWennberg Richard eWennberg Carmela eTartaglia Carmela eTartaglia Jen-Kai eChen Jen-Kai eChen Charles eTator Charles eTator |
author_sort |
Michelle eKeightley |
title |
Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. |
title_short |
Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. |
title_full |
Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. |
title_fullStr |
Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. |
title_full_unstemmed |
Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review. |
title_sort |
is there evidence for neurodegenerative change following traumatic brain injury in children and youth? a scoping review. |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2014-03-01 |
description |
While generalized cerebral atrophy and neurodegenerative change following traumatic brain injury (TBI) is well recognized in adults, it remains comparatively understudied in the pediatric population, suggesting that research should address the potential for neurodegenerative change in children and youth following TBI. This focused review examines original research findings documenting evidence for neurodegenerative change following TBI of all severities in children and youth. Our relevant inclusion and exclusion criteria identified a total of 16 articles for review. Taken together, the studies reviewed suggest there is evidence for long-term neurodegenerative change following TBI in children and youth. In particular both cross-sectional and longitudinal studies revealed volume loss in selected brain regions including the hippocampus, amygdala, globus pallidus, thalamus, periventricular white matter, cerebellum and brain stem as well as overall decreased whole brain volume and increased CSF and ventricular space. Diffusion Tensor Imaging (DTI) studies also report evidence for decreased cellular integrity, particularly in the corpus callosum. Sensitivity of the hippocampus and deep limbic structures in pediatric populations are similar to findings in the adult literature and we consider the data supporting these changes as well as the need to investigate the possibility of neurodegenerative onset in childhood associated with mTBI. |
topic |
Traumatic Brain Injury neurodegeneration pediatric chronic traumatic encephalopathy magnetic resonance imaging. |
url |
http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.00139/full |
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