Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease

Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease

Herpes simplex virus infections have been described in the medical literature for centuries, yet the the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatments. Additionally, the details of the inhibition...

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Bibliographic Details
Main Authors: Juliana F. R. Mello, Nathália C. Botelho, Alessandra M. T. Souza, Riethe Oliveira, Monique A. Brito, Bárbara de A. Abrahim-Vieira, Ana Carolina R. Sodero, Helena C. Castro, Lucio M. Cabral, Leonardo A. Miceli, Carlos R. Rodrigues
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
herpesvirus
protease
molecular docking
comparative modeling
benzoxazinones
Online Access:http://www.mdpi.com/1420-3049/20/6/10689

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