Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity
Abstract Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In...
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2021-06-01
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Series: | npj Schizophrenia |
Online Access: | https://doi.org/10.1038/s41537-021-00163-2 |
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doaj-4c647b422637432a9c6148ebe20912ed2021-06-20T11:20:21ZengNature Publishing Groupnpj Schizophrenia2334-265X2021-06-01711910.1038/s41537-021-00163-2Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivitySimon Fish0Foteini Christidi1Efstratios Karavasilis2Georgios Velonakis3Nikolaos Kelekis4Christoph Klein5Nicholas C. Stefanis6Nikolaos Smyrnis7Laboratory of Cognitive Neuroscience and Sensorimotor Control, University Mental Health, Neurosciences and Precision Medicine Research Institute “COSTAS STEFANIS”Department of Medical Physics, National and Kapodistrian University of Athens, School of Medicine2nd Department of Radiology, National and Kapodistrian University of Athens, School of Medicine, University General Hospital “ATTIKON”2nd Department of Radiology, National and Kapodistrian University of Athens, School of Medicine, University General Hospital “ATTIKON”2nd Department of Radiology, National and Kapodistrian University of Athens, School of Medicine, University General Hospital “ATTIKON”2nd Department of Psychiatry, National and Kapodistrian University of Athens, School of Medicine, University General Hospital “ATTIKON”1st Department of Psychiatry, National and Kapodistrian University of Athens, School of Medicine, Eginition HospitalLaboratory of Cognitive Neuroscience and Sensorimotor Control, University Mental Health, Neurosciences and Precision Medicine Research Institute “COSTAS STEFANIS”Abstract Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In the present study eighty-nine participants divided into four groups (control chronic cannabis users and non-users; schizophrenia patient cannabis users and non-users) performed a two-choice decision task, preceded by monetary cues (high/low reward/punishment or neutral), while being scanned using functional magnetic resonance imaging. Reward and punishment anticipation resulted in activation of regions of interest including the thalamus, striatum, amygdala and insula. Chronic cannabis use and schizophrenia had opposing effects on reward anticipation sensitivity. More specifically control users and patient non-users showed faster behavioural responses and increased activity in anterior/posterior insula for high magnitude cues compared to control non-users and patient users. The same interaction pattern was observed in the activation of the right thalamus for reward versus punishment cues. This study provided evidence for interaction of chronic cannabis use and schizophrenia on reward processing and highlights the need for future research addressing the significance of this interaction for the pathophysiology of these conditions and its clinical consequences.https://doi.org/10.1038/s41537-021-00163-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Simon Fish Foteini Christidi Efstratios Karavasilis Georgios Velonakis Nikolaos Kelekis Christoph Klein Nicholas C. Stefanis Nikolaos Smyrnis |
spellingShingle |
Simon Fish Foteini Christidi Efstratios Karavasilis Georgios Velonakis Nikolaos Kelekis Christoph Klein Nicholas C. Stefanis Nikolaos Smyrnis Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity npj Schizophrenia |
author_facet |
Simon Fish Foteini Christidi Efstratios Karavasilis Georgios Velonakis Nikolaos Kelekis Christoph Klein Nicholas C. Stefanis Nikolaos Smyrnis |
author_sort |
Simon Fish |
title |
Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity |
title_short |
Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity |
title_full |
Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity |
title_fullStr |
Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity |
title_full_unstemmed |
Interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity |
title_sort |
interaction of schizophrenia and chronic cannabis use on reward anticipation sensitivity |
publisher |
Nature Publishing Group |
series |
npj Schizophrenia |
issn |
2334-265X |
publishDate |
2021-06-01 |
description |
Abstract Chronic cannabis use and schizophrenia are both thought to affect reward processing. While behavioural and neural effects on reward processing have been investigated in both conditions, their interaction has not been studied, although chronic cannabis use is common among these patients. In the present study eighty-nine participants divided into four groups (control chronic cannabis users and non-users; schizophrenia patient cannabis users and non-users) performed a two-choice decision task, preceded by monetary cues (high/low reward/punishment or neutral), while being scanned using functional magnetic resonance imaging. Reward and punishment anticipation resulted in activation of regions of interest including the thalamus, striatum, amygdala and insula. Chronic cannabis use and schizophrenia had opposing effects on reward anticipation sensitivity. More specifically control users and patient non-users showed faster behavioural responses and increased activity in anterior/posterior insula for high magnitude cues compared to control non-users and patient users. The same interaction pattern was observed in the activation of the right thalamus for reward versus punishment cues. This study provided evidence for interaction of chronic cannabis use and schizophrenia on reward processing and highlights the need for future research addressing the significance of this interaction for the pathophysiology of these conditions and its clinical consequences. |
url |
https://doi.org/10.1038/s41537-021-00163-2 |
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