SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES

SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES

Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives undera base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone(a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-h...

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Main Authors: Adel Zamri1, Jufrizal Syahri, Rudi Hendra, Yuharmen, Yuana Nurulita2, Yum Eryanti
Format: Article
Language:English
Published: Universitas Indonesia 2011-11-01
Series:Makara Seri Sains
Subjects:
antioxidant
anti-inflammatory
curcumin
toxicity
Online Access:http://journal.ui.ac.id/science/article/viewFile/1060/973
id doaj-4c6b2fc71f9940f980098d40716e4c49
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spelling doaj-4c6b2fc71f9940f980098d40716e4c492020-11-24T23:05:44ZengUniversitas IndonesiaMakara Seri Sains1693-66712011-11-01152117123SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIESAdel Zamri1Jufrizal SyahriRudi HendraYuharmenYuana Nurulita2,Yum EryantiThree types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives undera base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone(a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c)which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMRspectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatoryactivities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presenceof hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activitieshttp://journal.ui.ac.id/science/article/viewFile/1060/973antioxidantanti-inflammatorycurcumintoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Adel Zamri1
Jufrizal Syahri
Rudi Hendra
Yuharmen
Yuana Nurulita2,
Yum Eryanti
spellingShingle Adel Zamri1
Jufrizal Syahri
Rudi Hendra
Yuharmen
Yuana Nurulita2,
Yum Eryanti
SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
Makara Seri Sains
antioxidant
anti-inflammatory
curcumin
toxicity
author_facet Adel Zamri1
Jufrizal Syahri
Rudi Hendra
Yuharmen
Yuana Nurulita2,
Yum Eryanti
author_sort Adel Zamri1
title SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
title_short SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
title_full SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
title_fullStr SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
title_full_unstemmed SYNTHESIZING DERIVATIVES FROM CYCLOPENTANONE ANALOGUE CURCUMIN AND THEIR TOXIC, ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES
title_sort synthesizing derivatives from cyclopentanone analogue curcumin and their toxic, antioxidant and anti-inflammatory activities
publisher Universitas Indonesia
series Makara Seri Sains
issn 1693-6671
publishDate 2011-11-01
description Three types of cyclopentanone derivatives have been synthesized from aromatic aldehyde and ketone derivatives undera base condition through aldol condensation. These cyclopentanone products were 2,5-dibenzylidene-cyclopentanone(a), 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (b), and 2,5-bis-(4-hydroxy-benzylidene)-cyclopentanone (c)which has a yield of 63-99%. The chemical structure of these compounds were determined using UV, IR and NMRspectroscopy. In order to clarify the role of hydroxyl and amine moieties, toxic, antioxidant and anti-inflammatoryactivities were carried out. The toxic test indicated that the compounds showed strong toxicity. In addition, the presenceof hydroxyl and amine groups on both rings of curcumin increased the antioxidant and anti-inflammatory activities
topic antioxidant
anti-inflammatory
curcumin
toxicity
url http://journal.ui.ac.id/science/article/viewFile/1060/973
work_keys_str_mv AT adelzamri1 synthesizingderivativesfromcyclopentanoneanaloguecurcuminandtheirtoxicantioxidantandantiinflammatoryactivities
AT jufrizalsyahri synthesizingderivativesfromcyclopentanoneanaloguecurcuminandtheirtoxicantioxidantandantiinflammatoryactivities
AT rudihendra synthesizingderivativesfromcyclopentanoneanaloguecurcuminandtheirtoxicantioxidantandantiinflammatoryactivities
AT yuharmen synthesizingderivativesfromcyclopentanoneanaloguecurcuminandtheirtoxicantioxidantandantiinflammatoryactivities
AT yuananurulita2 synthesizingderivativesfromcyclopentanoneanaloguecurcuminandtheirtoxicantioxidantandantiinflammatoryactivities
AT yumeryanti synthesizingderivativesfromcyclopentanoneanaloguecurcuminandtheirtoxicantioxidantandantiinflammatoryactivities
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