Moringa oleifera leaf extracts protect BMSC osteogenic induction following peroxidative damage by activating the PI3K/Akt/Foxo1 pathway

Moringa oleifera leaf extracts protect BMSC osteogenic induction following peroxidative damage by activating the PI3K/Akt/Foxo1 pathway

Abstract Objective We aimed to investigate the therapeutic effects of Moringa oleifera leaf extracts on osteogenic induction of rat bone marrow mesenchymal stem cells (BMSCs) following peroxidative damage and to explore the underlying mechanisms. Methods Conditioned medium was used to induce osteoge...

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Bibliographic Details
Main Authors: Meiling Liu, Haifeng Ding, Hongzhi Wang, Manfeng Wang, Xiaowei Wu, Lu Gan, Luyang Cheng, Xianglu Li
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Moringa oleifera leaf extracts
Bone marrow mesenchymal stem cells
Osteogenic induction
Hydrogen peroxide
PI3K/Akt pathway
Foxo1
Online Access:https://doi.org/10.1186/s13018-021-02284-x

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